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ModelsTalemi2015 - Persistent telomere-associated DNA damage foci (TAF), a measure to predict cancer risks
A Robust Model of DNA Damage Dynamics. Rasgou Talemi and Schaber, 12.20.2014.
2016-02-11 | MODEL1412200000 | BioModels
ModelsMa2005-digital response of p53 to DNA damage-ATM Activation Module
Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows dependence on the radiation dose. We present a model of this phenomenon. In our model, double-strand break (DSB) ...
2020-05-13 | MODEL2005130001 | BioModels
UnknownA p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.
Not available
S-EPMC3050855 | biostudies-literature
ProteomicsA metabolic map of the DNA damage response identifies PRDX1 in nuclear ROS scavenging and aspartate synthesis
While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes and processes that are essential when cells are exposed to DNA damage. By inte...
ORGANISM(S): Homo sapiens (Human) 
2023-03-31 | PXD035532 | Pride
Dna damage response  peroxiredoxin 1  reactive oxygen species scavenging  electron transport chain  chromatin  aspartate metabolism 
UnknownPhosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Not available
S-EPMC6561707 | biostudies-literature
Unknownγ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000).
Not available
S-EPMC6485439 | biostudies-literature
UnknownPersistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome.
Not available
S-EPMC6747728 | biostudies-literature
UnknownPhosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage.
Not available
S-EPMC86718 | biostudies-literature
ProteomicsInhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Expression of tryptophan 2,3-dioxygenase (TDO) is a determinant of malignancy in gliomas through kynurenine (KYN) signaling. We report that inhibition of TDO activity attenuated recovery from replication stress and increased the genotoxic effects of bis-chloroethylnitrosourea (BCNU). Activation of t...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022351 | Pride
Dna repair Dna damage Tryptophan 2 Kynurenine Replication stress 3-dioxygenase Dna replication 
UnknownStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.
Not available
S-EPMC2492745 | biostudies-literature
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