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MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
MetabolomicsUrinary metabolomics reveals kynurenine pathway perturbation in newborns with transposition of great arteries after surgical repair

INTRODUCTION: Transposition of the great arteries (TGA) is a cyanotic congenital heart defect that requires surgical correction, with the use of cardiopulmonary-bypass (CPB), usually within 3 weeks of life. The use of CPB in open heart surgery results in brain hypoperfu...

2020-04-15 | MTBLS946 | MetaboLights
MetabolomicsEnterotoxigenic Bacteroides fragilis Exacerbates Alcoholic Liver Disease by Driving Host Metabolic Reprogramming via the Tryptophan-Kynurenine-Retinol Pathway

Background & Aims: Alcoholic liver disease (ALD) is a major public health concern. Gut dysbiosis plays a critical role in its pathogenesis, yet the specific microbial and functional shifts driving ALD progression require further elucidation. This study aims to characterize these alterations a...

2026-02-06 | MTBLS13858 | MetaboLights
MetabolomicsEnterotoxigenic Bacteroides fragilis exacerbates alcoholic liver disease progression through kynurenine mediated AMPK signaling inhibition and retinoic acid depletion

Abstract Background & Aims: Alcoholic liver disease (ALD) pathogenesis involves gut microbiota dysbiosis, but specific pathobionts and mechanisms remain unclear. This study investigated the role of patient-derived enterotoxigenic Bacteroides fragilis (ETBF) in ALD progression and its underlyi...

2026-09-07 | MTBLS15572 | MetaboLights
MetabolomicsEnterotoxigenic Bacteroides fragilis Exacerbates Alcoholic Liver Disease by Driving Host Metabolic Reprogramming via the Tryptophan-Kynurenine-Retinol Pathway

Background & Aims: Alcoholic liver disease (ALD) is a major public health concern. Gut dysbiosis plays a critical role in its pathogenesis, yet the specific microbial and functional shifts driving ALD progression require further elucidation. This study aims to characterize these alterations a...

2026-01-10 | MTBLS13649 | MetaboLights
MetabolomicsEnterotoxigenic Bacteroides fragilis Exacerbates Alcoholic Liver Disease by Driving Host Metabolic Reprogramming via the Tryptophan-Kynurenine-Retinol Pathway

Background & Aims: Alcoholic liver disease (ALD) is a major public health concern. Gut dysbiosis plays a critical role in its pathogenesis, yet the specific microbial and functional shifts driving ALD progression require further elucidation. This study aims to characterize these alterations a...

2026-01-10 | MTBLS13650 | MetaboLights
TranscriptomicsGene expression analysis of the human glioma cell line U87MG
Identification of genes and pathways regulated by kynurenine in human glioma cells Total RNA from U87MG cells was extraced after 8h or 24h of treatment with 100µM kynurenine and compared to untreated control.
ORGANISM(S): Homo sapiens 
2010-11-11 | E-GEOD-25272 | biostudies-arrayexpress
GenomicsKynurenine treatment of herpesivrus stimulated iCD103 dendritic cells
Kynurenine treatment of herpesivrus stimulated iCD103 dendritic cells
PRJNA672924 | ENA
ModelsDalviGarcia2021 - Dopaminergic and Serotonergic-Kynurenine model
A mathematical model predicting a novel role of the dopamine and serotonin metabolites DOPAL and 5-HIAL in the ethiology of depression, which is facilitated through increased cortisol levels.
2021-05-11 | MODEL2103060001 | BioModels
ProteomicsRecombinant Protein Spectral Library (rPSL) DIA-MS Method Improves Identification and Quantification of Low-Abundance Cancer-Associated and Kynurenine Pathway Proteins
Data-independent acquisition mass spectrometry (DIA-MS) is a powerful tool for quantitative proteomics, but a well-constructed reference spectral library is crucial to optimize DIA analysis, particularly for low-abundance proteins. In this study, we evaluate the efficacy of a recombinant protein spe...
ORGANISM(S): Homo sapiens (Human) 
2025-05-15 | PXD061696 | Pride
Snap frozen tissues Rpsl Dia-ms Cancer- associated proteins Cell lysates Kynurenine pathway proteins Recombinant protein spectral library 
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