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CRISPR–Cas systems provide adaptive immunity in prokaryotes by targeting and degrading invasive genetic elements. Among them, the type I-F2 system represents the most compact type I CRISPR–Cas system, distinguished by the absence of small and large subunits. These subunits are otherwise essential fo...
ORGANISM(S): Shewanella putrefaciens CN-32 
2026-03-09 | PXD068253 | Pride
pAgo-induced DNA interference protects bacteria from invader DNA [smDNA]
pAgo-induced DNA interference protects bacteria from invader DNA [gDNA]
The peripheral circadian oscillator plays an essential role in synchronizing local physiology to operate in a circadian manner via regulation of the expression of clock-controlled genes. In the murine uterus, the endometrial stromal cells undergo proliferation and differentiation into decidual cells...
ORGANISM(S): Rattus norvegicus 
We used all five current human African trypanosomiasis drugs for genome-scale RNA interference (RNAi) target sequencing (RIT-seq) screens in Trypanosoma brucei, revealing the transporters, organelles, enzymes and metabolic pathways that function to facilitate anti-trypanosomal drug action. RIT-seq p...
ORGANISM(S): Trypanosoma brucei 
RNA interference-independent reprogramming of DNA methylation in Arabidopsis
The impact of global climate change on the transmission dynamics of infectious diseases is the subject of extensive debate. The transmission of mosquito-borne viral diseases is particularly complex, with climatic variables directly affecting many parameters associated with the prevalence of disease ...
ORGANISM(S): Aedes albopictus 
Argonaute proteins and their small RNA co-factors short interfering RNAs (siRNAs) are known to inhibit gene expression at the transcriptional and post-transcriptional levels. In Caenorhabditis elegans, the Argonaute CSR-1 binds thousands of endogenous siRNAs (endo-siRNAs) antisense to germline trans...
ORGANISM(S): Caenorhabditis elegans 
pAgo-induced DNA interference protects bacteria from invader DNA
Meiotic prophase length modulates Tel1-dependent DNA double-strand break interference
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