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ProteomicsDNA methyltransferase (DNMT) associated proteins in human malaria parasite Plasmodium falciparum
This study identified Plasmodium falciparum DNA methyltransferase (DNMT)associated proteins in parasite cytosol and nucleus, including RNA binding proteins and AP2-domain containing proteins, indicating this protein is involved in RNA process and transctiptional regulation.
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2023-07-20 | PXD032860 | Pride
Plasmodium falciparum Dna methyltransferase (dnmt) 
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
GenomicsCpG underrepresentation and the new bacterial CpG specific DNA methyltransferase M.MpeI
The CpG depleted Mycoplasma penetrans harbors a CpG specific C5 methyltransferase. The aim of this experiment was to confirm the specificity of the methyltransferase in vivo and in vitro. Genomic DNA from Mycoplasma penetrans and Escherichia coli genomic DNA that either was or was not methylated in ...
ORGANISM(S): Escherichia coli 
2012-11-29 | E-GEOD-41022 | biostudies-arrayexpress
TranscriptomicsSmall RNA mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation
Mammalian cells contain copious amounts of RNA including both coding and non-coding RNA (ncRNA). Generally the ncRNAs function to regulate gene expression at the transcriptional and post-transcriptional level. Among ncRNA, the long ncRNA and small ncRNA can affect histone modification, DNA methylati...
ORGANISM(S): Homo sapiens 
2015-04-21 | E-GEOD-68027 | biostudies-arrayexpress
GenomicsDNA Methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting Polycomb target genes
Cancer cell phenotypes are partially determined by epigenetic specifications such as DNA methylation. Metastasis development is a late event in cancerogenesis and might be associated with epigenetic alterations. Here, we analyzed genome wide DNA methylation changes that were associated with pro-meta...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-44390 | biostudies-arrayexpress
TranscriptomicsCritical Requirement of the DNA Methyltransferase, Dnmt1, for the Development and Function of Foxp3+ Regulatory T Cells
We investigated the role of DNMT1 in immune homeostasis by generating mice lacking DNMT1 in Foxp3+ T-regulatory (Treg) cells. These mice showed decreased peripheral Foxp3+ Tregs, complete loss of Foxp3+ Treg suppressive functions in vitro and in vivo, and died from autoimmunity by 3-4 weeks unless t...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-27434 | biostudies-arrayexpress
GenomicsDnmt2-dependent methylomes lack biologically relevant DNA methylation patterns
Several organisms belonging to diverse animal groups have retained Dnmt2 as their only bona fide DNA methyltransferase gene. However, recent studies have shown that Dnmt2 functions as a tRNA methyltransferase, which prompted us to analyze the methylomes of Dnmt2-only organisms at single-base resolut...
ORGANISM(S): Mus musculus 
2013-05-06 | E-GEOD-42170 | biostudies-arrayexpress
TranscriptomicsImmune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers [methylation]
Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidin...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-57342 | biostudies-arrayexpress
ProteomicsThe type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
Decitabine and Azacytidine are considered as epigenetic drugs that induce DNA-methyltransferase (DNMT)-DNA crosslinks, resulting in DNA-hypomethylation and -damage. Although they are already applied against myeloid cancers, important aspects of their mode of action remain unknown, highly limiting th...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-19 | PXD045353 | Pride
Spatial proteomics 5-aza-2'-deoxycytidine Protein-dna crosslinks Azacytidine 
TranscriptomicsDecitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines
Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors.
ORGANISM(S): Homo sapiens 
2022-10-20 | E-MTAB-12225 | biostudies-arrayexpress
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