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GenomicsSignatures of mismatch repair deficiency in cancer genomes
DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient tumors and observed that mutation rates were drastically increased relative to MMR-proficient end...
EGAS00001000182 | EGA
ProteomicsMCM9 is Required for Mammalian DNA Mismatch Repair
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects innate DNA polymerase infidelities during replication to maintain genomic integrity. Defects in a subset of MMR genes are associated with hereditary non-polyposis colon cancer and some other sporadic cancers, highlighting...
ORGANISM(S): Homo sapiens (Human) 
2015-08-19 | PXD000212 | Pride
Mcm9 human dna replication helicase mmr mismatch repair 
Genomicsena-DATASET-VIB-29-07-2013-12:55:51:690-38 - samples
DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient endometrial tumors.
EGAD00001000641 | EGA
TranscriptomicsTranscription profiling of three human colorectal adenocarcinoma cells lines two which are mismatch repair deficient to characterize the post-transcriptional profile
characterize the post-transcriptional profile of mismatch repair-deficient colon cancer
ORGANISM(S): Homo sapiens 
2008-07-15 | E-MEXP-1696 | biostudies-arrayexpress
GenomicsUnraveling mutagenic processes influencing the tumor mutational patterns of individuals with Constitutional Mismatch Repair Deficiency
Constitutional mismatch repair deficiency (CMMRD), caused by bi-allelic germline variants in one of the mismatch repair (MMR) genes, is a childhood cancer predisposition syndrome that often results in the development of multiple tumors early in life. A better understanding of mutational processes...
EGAS00001007660 | EGA
ProteomicsTGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells
DNA mismatch repair-deficient colorectal tumors (CRC) frequently show coding microsatellite frameshift mutations in the MSI tumor driver Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) leading to cellular alteration of MSI tumor cells [Lee, J., Warnken, U., Schnölzer, M., Gebert, J. & Kopit...
ORGANISM(S): Homo sapiens (Human) 
2017-04-07 | PXD005620 | Pride
Dna mismatch repair deficiency Lc-msms Transforming growth factor beta receptor type 2 Colorectal cancer Microsatellite instability Exosomes Proteomics 
GenomicsMismatch repair deficiency is not sufficient to increase tumor immunogenicity
Mouse models of mismatch repair deficiency
PRJEB56609 | ENA
TranscriptomicsGene expression analysis of B cell lymphomas from representative IµHABcl6, IµHABcl6 Ung-/- Msh2-/-, and IµHABcl6 Msh2-/- mouse models.
Somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes are genomic modification events that occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation induced cytidine deaminase (AID). Resulting uracil-guani...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-48304 | biostudies-arrayexpress
ProteomicsMismatch repair deficiency is not sufficient to elicit tumor immunogenicity
Tandem mass tag spectrometry was performed on eluted peptides from 8 single cell clones derived from a DNA mismatch repair deficient (MMRd) lung cancer cell line, which was derived ex vivo from tumors induced autochthonously in the lungs of mice in the MMRd models described in Westcott, PMK, et al.,...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-04 | MSV000092096 | MassIVE
GenomicsGenetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
PRJEB56611 | ENA
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