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GenomicsRecG Directs DNA Synthesis During Double-Strand Break Repair [ChIP-seq]
In the bacterium Escherichia coli, RecG directs DNA synthesis during the repair of DNA double-strand breaks by homologous recombination. Examination of RecA binding during double-strand break repair in Escherichia coli in the presence and absence of RecG protein
ORGANISM(S): Escherichia coli 
2016-05-19 | E-GEOD-77181 | biostudies-arrayexpress
MetabolomicsMetabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells
Genomic instability is one of the hallmarks of cancer. Several chemotherapeutic drugs and radiotherapy induce DNA damage to prevent cancer cell replication. Cells in turn activate different DNA damage response (DDR) pathways to either repair the damage or induce cell death. These DDR pathways also e...
2015-08-01 | MTBLS177 | MetaboLights
TranscriptomicsA Role for Small RNAs in DNA Double-Strand Break Repair
Here we identify a novel class of small RNAs that are ~21-nucleotide in length and are produced from the sequences in the vicinity of DNA double strand break (DSB) sites in Arabidopsis and humans. We named them diRNAs for DSB-induced small RNAs. In Arabidopsis, the biogenesis of diRNAs requires the ...
ORGANISM(S): Arabidopsis thaliana 
2012-03-26 | E-GEOD-36338 | biostudies-arrayexpress
TranscriptomicsMonitoring Homology Search during DNA Double-Strand Break Repair in vivo
Homologous recombination (HR) is crucial for genetic exchange, accurate repair of DNA double-strand breaks and pivotal for genome integrity. HR uses homologous sequences for repair, but how homology search, the exploration of the genome for homologous DNA sequences, is conducted in the nucleus remai...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-21 | E-GEOD-44844 | biostudies-arrayexpress
TranscriptomicsRecG Directs DNA Synthesis During Double-Strand Break Repair [Chromosomal marker frequency analysis]
In the bacterium Escherichia coli, RecG directs DNA synthesis during the repair of DNA double-strand breaks by homologous recombination. Chromosomal marker frequency analysis (MFA) following induction of a DSB in the absence and presence of RecG
ORGANISM(S): Escherichia coli 
2016-05-19 | E-GEOD-77183 | biostudies-arrayexpress
ProteomicsRif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined. Here, we demonstrate that Rif1 is S-acylated within its conse...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-04-15 | PXD012137 | Pride
Non-homologous end-joining Dna double-strand break repair Palmitoylation Yeast Rif1 s-acylation 
TranscriptomicsRecG Directs DNA Synthesis During Double-Strand Break Repair
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Escherichia coli 
2016-05-19 | E-GEOD-77184 | biostudies-arrayexpress
TranscriptomicsA histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.
Wildtype and set2delta strains, with samples taken at t=0 and following 30 minutes treatment with 5 µg/ml bleomycin.
ORGANISM(S): Schizosaccharomyces pombe 
2014-06-09 | E-MTAB-2549 | biostudies-arrayexpress
ProteomicsATM Inhibition Exploits Checkpoint Defects and ATM-Dependent Double Strand Break Repair in TP53-Mutant Glioblastoma
Determining the balance between DNA double strand break repair (DSBR) pathways is essential for understanding treatment response in cancer. We report a novel method for simultaneously measuring non-homologous end joining (NHEJ), homologous recombination (HR), and microhomology-mediated end joining (...
ORGANISM(S): Homo sapiens (Human) 
2024-03-08 | PXD047837 | Pride
Dna double strand break repair Tp53-mutant glioblastoma Atm inhibition 
GenomicsDNA methylation is stable after MMEJ and NHEJ double strand break repair
DNA double strand breaks (DSBs) are a major source of mutations. Both non-homologous-end-joining (NHEJ) and microhomology-mediated-end-joining (MMEJ) DSB repair pathways are error prone and produce deletions, which can lead to cancer. DSBs also lead to epigenetic changes, including demethylation, wh...
ORGANISM(S): Homo sapiens 
2022-09-11 | E-MTAB-12037 | biostudies-arrayexpress
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