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ProteomicsDONSON encodes a novel replication fork protection factor mutated in 2 microcephalic dwarfism.
To ensure efficient genome duplication, cells have evolved a multitude of factors that promote unperturbed DNA replication, and protect, repair and restart damaged forks. Here we identify DONSON as a novel fork protection factor, and report biallelic DONSON mutations in individuals with microcephali...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080704 | MassIVE
GenomicsDONSON encodes a novel replication fork protection factor mutated in microcephalic dwarfism.
To ensure efficient genome duplication, cells have evolved a multitude of factors that promote unperturbed DNA replication, and protect, repair and restart damaged forks. Here we identify DONSON as a novel fork protection factor, and report biallelic DONSON mutations in 29 individuals with microceph...
EGAS00001002224 | EGA
ProteomicsThe H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks Through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse
The proteins from the Fanconi Anemia (FA) pathway of DNA repair maintain DNA replication fork integrity by preventing the unscheduled degradation of nascent DNA at regions of stalled replication forks. Here, we ask if the bacterial pathogen H. pylori exploits the fork stabilisation machinery to gene...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD031168 | Pride
H. pylori  dna replication  caga  dna double strand breaks  fanconi anemia  h2ax 
ProteomicsKi-67 is necessary during DNA replication for forks protection and genome stability
Ki-67 molecular functions and properties have remained quite obscure for a long time, despite its importance as a major proliferation marker in clinic. Only recently it has been shown that Ki-67 has a major role in the formation of the mitotic chromosome periphery compartment, and it is a protein ph...
ORGANISM(S): Homo sapiens (Human) 
2024-04-13 | PXD037513 | Pride
Ki-67 Silac Genome stability Cell cycle Dna replication 
ProteomicsProtection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-14 | PXD031972 | Pride
Sq motifs Rif1 Dsb resection inhibition Dna replication fork protection Intrinsically disordered region 
UnknownPDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.
Not available
S-EPMC6952610 | biostudies-literature
UnknownRADX Modulates RAD51 Activity to Control Replication Fork Protection.
Not available
S-EPMC6086571 | biostudies-literature
GenomicsAcetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks
Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks
PRJNA1294749 | ENA
UnknownUSP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.
Not available
S-EPMC6390489 | biostudies-literature
UnknownHomologous recombination as a replication fork escort: fork-protection and recovery.
Not available
S-EPMC4030885 | biostudies-literature
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