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MetabolomicsMulti-omics analysis reveals immune-metabolic dysregulation in DNASE1L3-deficient mouse liver

This study investigates the role of DNASE1L3 deficiency in hepatic immune and metabolic regulation. Using transcriptomics, proteomics, and metabolomics, we characterize changes in Kupffer cell polarization, ER stress, iron metabolism, and ferroptosis in DNASE1L3 knockout mice.'

2025-10-25 | MTBLS13057 | MetaboLights
ProteomicsTMT-Based Quantitative Proteomic Profiling of DNASE1L3-Deficient and Wild-Type Mouse Livers
This study investigates the impact of DNASE1L3 deficiency on hepatic immune–metabolic homeostasis using TMT-based quantitative proteomics. Liver tissues from 8-week-old wild-type (WT) and DNASE1L3 knockout (KO) mice were analyzed by LC-MS/MS. Differential protein expression and pathway enrichment an...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD068786 | Pride
Proteomics Tmt Ferroptosis Liver Kupffer cells Dnase1l3 Lc-ms/ms Nafld 
GenomicsDnase1l3 enhances antitumor immunity and suppresses tumor progression [bulk RNAseq]
Dnase1l3 enhances antitumor immunity and suppresses tumor progression [bulk RNAseq]
PRJNA803223 | ENA
TranscriptomicsB-cell-intrinsic DNase1L3 is essential for T-cell-independent type II response in mice
T-cell independent type II (TI-II) antigens, such as capsular polysaccharides, have multivalent epitope, which induce B cell activation, plasma cell differentiation and antibody production by strongly cross-linking B cell receptors. However, the mechanism of B cell activation by TI-II antigens remai...
ORGANISM(S): Mus musculus 
2023-12-18 | GSE221036 | GEO
GenomicsB-cell-intrinsic DNase1L3 is essential for T-cell-independent type II response in mice
B-cell-intrinsic DNase1L3 is essential for T-cell-independent type II response in mice
PRJNA912647 | ENA
UnknownArg206Cys substitution in DNASE1L3 causes a defect in DNASE1L3 protein secretion that confers risk of systemic lupus erythematosus.
Not available
S-EPMC8142439 | biostudies-literature
UnknownStructural features of Dnase1L3 responsible for serum antigen clearance.
Not available
S-EPMC9381713 | biostudies-literature
GenomicsDnase1l3 enhances antitumor immunity and suppresses tumor progression [scRNAseq]
Dnase1l3 enhances antitumor immunity and suppresses tumor progression [scRNAseq]
PRJNA803189 | ENA
UnknownDNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer.
Not available
S-EPMC10544201 | biostudies-literature
UnknownDeficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice.
Not available
S-EPMC10843819 | biostudies-literature
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