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MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
TranscriptomicsGenome-wide location analysis of Dnmt3a-mediated epigenetic regulation in murine postnatal subventricular zone (SVZ) neural stem cells (NSCs) [NimbleGen]
DNA methylation at proximal promoters facilitates lineage restriction by silencing cell-type specific genes. However, euchromatic DNA methylation frequently occurs in regions outside promoters. The functions of such non-proximal promoter DNA methylation are unclear. Here we show that the de novo DNA...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-22475 | biostudies-arrayexpress
TranscriptomicsMouse lung tumor tissue: Dnmt3a KO vs. Dnmt3a WT
Transcriptional profiling of mouse lung tumors comparing Dnmt3a KO/K-ras G12D mutant with Dnmt3a WT/K-ras G12D mutant. The goal is to search for the difference of mRNA abundance between Dnmt3a KO and WT tumors. Two-condition experiment, KO vs. WT tissure. Biological replicates: 12.
ORGANISM(S): Mus musculus 
2011-10-25 | E-GEOD-32415 | biostudies-arrayexpress
GenomicsDnmt3a protects active chromosome domains against cancer-associated hypomethylation
The results of the study uncover conserved features of cancer methylomes and provide a mechanistic explanation for the tumor-promoting effects of Dnmt3a mutations. Whole genome methylation analysis of Mus musculus. Five samples were analyzed, one control sample containing normal healthy lung tissue,...
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-38651 | biostudies-arrayexpress
TranscriptomicsDnmt3a-dependent non-promoter DNA methylation facilitates transcription of neurogenic genes
This SuperSeries is composed of the following subset Series: GSE22473: Murine postnatal subventricular zone (SVZ) neural stem cells (NSCs): Wild-type (WT) vs. Dnmt3a-null (KO) GSE22474: Genome-wide location analysis of Dnmt3a-mediated epigenetic regulation in murine postnatal subventricular zone (SV...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-22476 | biostudies-arrayexpress
GenomicsLarge conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a (CMS bisulfite-seq)
Gains and losses in DNA methylation are prominent genomic features of all mammalian cell types. To gain insight into mechanisms that could promote shifts in DNA 5-hydroxymethylation (5hmc) patterns and thus contribute to cell fate, including malignant transformation, we performed genome-wide mappin...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-53742 | biostudies-arrayexpress
GenomicsDNA methylation of dnmt3a deficient Kras lung tumors and dnmt3a wt Kras lung tumors
To examine whether Dnmt3a deficiency resulted in genomic methylation changes we performed an unbiased methylome analysis. Methylated DNA isolated from three Dnmt3a deficient and two WT tumors was immunoprecipitated and subjected to high throughput sequencing (MeDIP-Seq). We observed that genes that ...
ORGANISM(S): Mus musculus 
2011-10-25 | E-GEOD-32484 | biostudies-arrayexpress
ProteomicsThe interaction between DNMT3A with H3Kc36me2 modified nucleosomes
DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns, essential for the dynamic organization of vertebrate genomes. However, the mechanisms underlying DNMT3A1's recruitment and function within different chromatin environments remain unclear...
ORGANISM(S): Homo sapiens (Human) 
2024-12-07 | PXD046529 | Pride
Dnmt3a Crosslink Nucleosomes 
TranscriptomicsSequence preference of DNMT3A/B dictates genome-wide DNA methylation signature
Exploring the sequence specificity of methylation by DNMT3A and DNMT3B using bisulfite sequencing in E.coli and publicly available mouse and human datasets
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2020-06-22 | E-MTAB-8406 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of peritoneal macrophages Transcriptomes of Dnmt3a macrophage conditional knockout mouse
Purpose:The purpose of this study is to measure the gene expression profile in Dnmt3a conditional knockout macrophages. Methods:Dnmt3a conditional knockout macrophages mRNA profiles were generated by deep sequencing,using Illumina. Results: We mapped about 20 million sequence reads per sample to the...
ORGANISM(S): Mus musculus 
2016-05-30 | E-GEOD-74750 | biostudies-arrayexpress
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