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Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
Human airway epithelial cells cultured in vitro at air-liquid interface (ALI) form a pseudostratified epithelium that forms tight junctions and cilia, and produces mucin, and are widely used as a model of differentiation, injury, and repair. To assess how closely the transcriptome of ALI epithelium ...
ORGANISM(S): Homo sapiens 
Methicillin resistant Staphylococcus aureus (MRSA) infection is becoming refractory to existing antibiotic therapy owing to the inherent ability of S. aureus to develop rapid resistance and is considered a major threat to public health. We found that a natural isolate of Bacillus pumilus from the C...
ORGANISM(S): Staphylococcus aureus 
Rosuvastatin is a quite known lipid-lowering agent generally used for hypercholesterolemia treatment and coronary artery diseases prevention. There is substantial inter-individual variability in the absorption of statins usually caused by genetic polymorphisms leading to variation in the correspondi...
2021-10-29 | MTBLS3128 | MetaboLights
Salvador Chulián, Álvaro Martínez-Rubio, Anna Marciniak-Czochra, Thomas Stiehl, Cristina Blázquez Goñi, Juan Francisco Rodríguez Gutiérrez, Manuel Ramírez Orellana, Ana Castillo Robleda, Víctor M. Pérez-García & María Rosa. Dynamical properties of feedback signalling in B lymphopoiesis: A mathematic...
2024-09-02 | BIOMD0000001056 | BioModels
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