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TranscriptomicsComparison of M. tuberculosis and M. bovis BCG in diluted whole blood cultures
Despite wide scale vaccination with Mycobacterium bovis BCG, the prevalence of tuberculosis remains high, reflecting the global variable efficacy of this vaccine against adult pulmonary TB. Characterisation of different immune responses to M. tuberculosis and M. bovis BCG would increase understandi...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-45386 | biostudies-arrayexpress
TranscriptomicsExcessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment
Background Identification of patients at risk of tuberculosis relapse following treatment would revolutionize clinical trials of new drugs and regimens and facilitate clinical management. The study aim was to determine whether tuberculosis patients who subsequently suffer relapse have different immu...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-67589 | biostudies-arrayexpress
TranscriptomicsTuberculosis Patients Blood Gene Expression Through Treatment (cured and end-of-treatment patients)
Background Accurate assessment of treatment efficacy would facilitate clinical trials of new anti-tuberculosis drugs. TB patients exhibit altered peripheral immunity which reverts during successful treatment. We hypothesised that these changes could be observed in whole blood transcriptome profiles...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-36238 | biostudies-arrayexpress
TranscriptomicsTuberculosis patients blood gene expression through treatment
Background Accurate assessment of treatment efficacy would facilitate clinical trials of new anti-tuberculosis drugs. TB patients exhibit altered peripheral immunity which reverts during successful treatment. We hypothesised that these changes could be observed in whole blood transcriptome profiles...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-31348 | biostudies-arrayexpress
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