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MetabolomicsMetabolomic Characterization of Knock-Out Mutants in Arabidopsis - Development of a Metabolite Profiling Database for Knock-Out Mutants in Arabidopsis (MeKO)
Despite recent intensive research efforts in functional genomics, the functions of only a limited number of Arabidopsis (Arabidopsis thaliana) genes have been determined experimentally. Thus, improving gene annotation remains a major challenge in plant science. Because metabolite profiling can chara...
2014-03-01 | MTBLS47 | MetaboLights
MetabolomicsEndoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants
Brassicaceae plants have a dual-cell type of chemical defense against herbivory. Here we show a novel single-cell defense involving endoplasmic reticulum (ER)-derived organelles (ER bodies) and the vacuoles. We identify various glucosinolates as endogenous substrates of the ER-body β-glucosidases BG...
2020-02-04 | MTBLS1383 | MetaboLights
TranscriptomicsDNA methylation data from mouse iPS cells, ES cells, and ntES cells
Genome-wide DNA methylation was studied to determine whether iPS cells retain epigenetic memory at loci associated with its tissue of origin. We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in mouse iPS cells. We isolated genomic DNA from mouse stem cells and hybrid...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22851 | biostudies-arrayexpress
TranscriptomicsHuman iPS cells and fibroblasts
This SuperSeries is composed of the following subset Series: GSE18226: Expression data from human iPS cells and fibroblasts GSE18227: DNA methylation data from human iPS cells and fibroblasts Refer to individual Series
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18111 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from human iPS cells and fibroblasts
DNA methylation is often inversely correlated with gene expression. We used custom Nimblegen microarrays to determine the relationship between DNA methylation and gene expression in 6 iPS cell lines and the fibroblasts from which they were derived. We isolated genomic DNA from iPS cells and fibrobla...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18227 | biostudies-arrayexpress
TranscriptomicsDonor cell type influences the epigenome and differentiation potential of human induced pluripotent stem cells
This SuperSeries is composed of the following subset Series: GSE27134: DNA methylation data from human iPS cells, ES cells, cord blood, and keratinocytes GSE27186: Expression data of human somatic cell types and induced pluripotent stem cells GSE31742: DNA methylation data from human keratinocyte-de...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-27224 | biostudies-arrayexpress
TranscriptomicsExpression data from human iPS cells and fibroblasts
DNA methylation is often inversely correlated with gene expression. We used expression microarrays to determine the relationship between DNA methylation and gene expression in 6 iPS cell lines and the fibroblasts from which they were derived. We isolated RNA from iPS cells and fibroblasts for which ...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18226 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from human keratinocyte-derived iPS cells (N9) and ES cells
Genome-wide DNA methylation of early and late passaged keratinocyte-derived iPS cells were compared to ES cells. We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in human keratinocyte-derived iPS cells and ES cells We isolated genomic DNA from human stem cells and s...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-31742 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from a separate set of human iPS cells and fibroblasts, and ES cells
We used custom Nimblegen microarrays to determine the DNA methylation profiles of iPS cells, ES cells, and fibroblasts. We isolated genomic DNA from iPS cells, ES cells, and fibroblasts and hybridized to custom-designed Nimblegen microarrays (CHARM arrays).
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-24820 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from human iPS cells, ES cells, cord blood, and keratinocytes
Genome-wide DNA methylation was studied to determine whether iPS cells retain epigenetic memory at loci associated with its tissue of origin. We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in human iPS cells, ES cells, and somatic cells We isolated genomic DNA from...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-27134 | biostudies-arrayexpress
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