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ProteomicsGlioma proteome - Quantitative proteomics reveals fundamental regulatory differences in oncogenic HRAS and IDH1 driven astrocytoma
In the present study, we applied a quantitative MS-based strategy to characterize the proteome and phosphoproteome in HRAS- or IDH1-driven glioma cells. We describe the driving roles of the MEK and PI3K signaling pathways in RAS-NHA cells, and uncover oncogenic signaling in other pathways. We highli...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD004945 | Pride
Phosphoproteomics Mek pi3k inhibition Primary vs. secondary glioblastoma Epigenetics 
ProteomicsThe Proteome Landscape of the Kingdoms of Life
Proteins preform the vast majority of functions in all biological domains but their large-scale investigation has lagged behind for technological reasons. Since the first essentially complete eukaryotic proteome was reported1, advances in mass spectrometry (MS)-based proteomics2 have enabled increas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-13 | MSV000085728 | MassIVE
ProteomicsThe Proteome Landscape of the Kingdoms of Life
Proteins preform the vast majority of functions in all biological domains but their large-scale investigation has lagged behind for technological reasons. Since the first essentially complete eukaryotic proteome was reported1, advances in mass spectrometry (MS)-based proteomics2 have enabled increas...
ORGANISM(S): Dictyostelium Discoideum (ncbitaxon:44689) Triticum Aestivum (ncbitaxon:4565) Escherichia Coli (ncbitaxon:562) Sus Scrofa Domesticus (ncbitaxon:9825) Gallus Gallus (ncbitaxon:9031) Rattus Norvegicus (ncbitaxon:10116) Homo Sapiens (ncbitaxon:9606) Danio Rerio (ncbitaxon:7955) Saccharomyces Cerevisiae (ncbitaxon:4932) Bos Taurus (ncbitaxon:9913) Drosophila Melanogaster (ncbitaxon:7227) Arabidopsis Thaliana (ncbitaxon:3702) Vitis Vinifera (ncbitaxon:29760) Mus Musculus (ncbitaxon:10090) Caenorhabditis Elegans (ncbitaxon:6239) 
2020-07-10 | MSV000085716 | MassIVE
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins, its diseases should affect the plasma proteome. Plasma Proteome Profiling of 48 patients with cirrhosis ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000084332 | MassIVE
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins its diseases should affect the plasma proteome. Plasma proteome profiling on 48 patients with cirrhosis o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084333 | MassIVE
ProteomicsRegion and cell-type resolved quantitative proteomic map of the human heart and its application to atrial fibrillation
The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins is still lacking. Here we determine the healthy human heart proteome by measuring 16 anatomical regions and three major car...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-03 | MSV000084410 | MassIVE
ProteomicsSpatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Human skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically charact...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-15 | MSV000088236 | MassIVE
ProteomicsPlasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specifi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-09-19 | MSV000084344 | MassIVE
ProteomicsT.litoralis DSM 5473 - Whole organism, SC (Muelleretal,nature2020)
abundance based on Spectral counting, Interaction consistency score: 3.1, Coverage: 12
ORGANISM(S): 523849 
2020-00-00 | 3126980404 | PAXDB
ProteomicsA.muciniphila ATCC BAA-835 - Whole organism, SC (Muelleretal,nature2020)
abundance based on Spectral counting, Interaction consistency score: 9.0, Coverage: 65
ORGANISM(S): 349741 
2020-00-00 | 1999420917 | PAXDB
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