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TranscriptomicsBMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
The transition from progenitor to differentiated cells is critical for successful organogenesis; subtle alterations in this process can lead to developmental disorders. The anterior heart field (AHF) encompasses a niche in which cardiac progenitors maintain their multipotent and undifferentiated nat...
ORGANISM(S): Gallus gallus 
2010-08-01 | E-GEOD-19698 | biostudies-arrayexpress
TranscriptomicsRNF20 and USP44 regulate embryonic stem cell differentiation by modulating H2B monoubiquitylation
Embryonic stem cells (ESCs) maintain high genomic plasticity, essential for their capacity to enter diverse differentiation pathways. Post-transcriptional modifications of chromatin histones play a pivotal role in maintaining this plasticity. We now report that one such modification, monoubiquitylat...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-33214 | biostudies-arrayexpress
TranscriptomicsDownregulation of LATS kinases alters p53 to promote cell migration
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-?B subunit. Moreover, it par...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-74493 | biostudies-arrayexpress
TranscriptomicsExpression data from colorectal cancer patients
The study consist of patients who presented at Memorial Sloan-Kettering Cancer Center with a colonic neoplasm between 1992 and 2004. Biological specimens used in this study include primary colon adenocarcinomas, adenomas, metastasis and corresponding normal mucosae. 390 expression arrays
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-41258 | biostudies-arrayexpress
TranscriptomicsCoupled pre-mRNA and mRNA dynamics unveil the operation strategies underlying transcriptional responses
Transcriptional responses to stimuli are regulated by tuning rates of transcript production and degradation. Here we show that stimulation-induced changes in transcript production and degradation rates can be inferred from simultaneously measured precursor mRNA (pre-mRNA) and mature mRNA profiles. O...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-24391 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of MDR2 knockout mice vs heterozygotes sampled at multiple time points in the early stages of liver carcinogenesis to identify the molecular mechanisms of HCC initiation and promotion
We studied the molecular mechanisms of hepatocellular carcinoma (HCC) initiation and promotion using the Mdr2-knockout (Mdr2-KO) mice at pre-cancerous stages of liver disease. These mice lack the liver-specific P-glycoprotein responsible for phosphatidylcholine transport across the canalicular membr...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4612 | biostudies-arrayexpress
TranscriptomicsNormal prostate cells were immortalized and cultured for 650 days till several transformation hallmarks were observed
Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a key causal role in tumorigenesis. According to an alternative view, chromosomal instabilities are mainly a common side effect o...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-23038 | biostudies-arrayexpress
TranscriptomicsmiR-10b*, a master inhibitor of the cell cycle, is downregulated in human breast tumors
Deciphering the molecular mechanisms involved in breast tumorigenesis has been the subject of extensive research in the last years; yet unpredictable response and development of resistance to adjuvant therapies remain major questions in the management of breast cancer patients. The power of miR expr...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-40525 | biostudies-arrayexpress
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