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TranscriptomicsA Genomics-Based Analysis of Relative Potencies of Dioxin-Like Compounds in Primary Rat Hepatocytes
A toxicogenomics approach was used to qualitatively and quantitatively compare gene expression changes in rat primary hepatocytes exposed to 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) or 2,3,7,8-tetrachlorodibenzofuran (TCDF). Hepatocytes from five individual rats were exposed for 24 hours to 11 co...
ORGANISM(S): Rattus norvegicus 
2014-01-01 | E-GEOD-49473 | biostudies-arrayexpress
TranscriptomicsThe role of yeast IME2 in early meiotic gene expression
We examined global RNA expression in S. cerevisiae wild type cells and ime2D cells (lacking the IME2 gene) that were induced to enter meiosis. These data have provided evidence that the Ime2 protein kinase is required for normal transcription of many genes that contain cell cycle box promoter elemen...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-30 | E-GEOD-26649 | biostudies-arrayexpress
TranscriptomicsIdentification of GATA1 transcriptional regulation in the megakaryoblastic cell line Meg01
chIP-on-chip analysis of GATA1 in the megakaryoblastic cell line Meg01. The IP was obtained with a GATA1 C-terminus antibody. The control sample was a normal goat IgG pull down done side by side with the GATA1 (C-20) antibody using the same soluble chromatin sample from non-treated Meg-01 cells. A ...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-43018 | biostudies-arrayexpress
TranscriptomicsOverexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic leukemia
Gene expression study of shRNA knockdown of GATA1 in the megakaryoblastic cell line Meg01. Cell culture samples from two Meg01 clones (GATA1 4-14 and GATA1 5-13) were compared against a negative control infection sample (GATA1-neg). Two dye-swap microarrays were completed for each clone.
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-42879 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiles Induced by the Aryl Hydrocarbon Receptor Agonists 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran and 2,3,4,7,8-Pentachlorodibenzofuran in Primary Rat Hepatocytes
Transcriptional profiling of primary rat hepatocytes exposed to high and low doses of three compounds, as well as untreated cells. All samples were co-hybridized with DMSO controls. A direct two-color experiment design, with each treated sample co-hybridized with a DMSO control. Hepatocytes derived...
ORGANISM(S): Rattus norvegicus 
2011-11-01 | E-GEOD-29095 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat esophagus treated with N-nitrosomethylbenzylamine to identify the effects of phenylethyl isothiocyanate on N-nitrosomethylbenzylamine-induced cytotoxicity
To date, there is little information on early molecular events in the development of N-nitrosomethylbenzylamine (NMBA) induced esophageal tumorigenesis and of the effects of chemopreventive agents on these events. In this study, we identified genes in rat esophagus that were differentially expressed...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6917 | biostudies-arrayexpress
TranscriptomicsThe unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy
Microarray gene expression profiling of lentivirus shRNA knockdown of the GATA1 gene in a DS AMkL cell line, CMK (harbors a mutated GATA1 gene and only expresses GATA1s). Cell culture samples from two CMK clones (CMK-5a and CMK-5b) were compared against a negative control infection sample (CMK-neg)....
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-32388 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease
Sex-differences in human liver gene expression were characterized on a genome-wide scale using a large liver sample collection, allowing for detection of small expression differences with high statistical power. 1,249 sex-biased genes were identified, 70% showing higher expression in females. Chromo...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-23766 | biostudies-arrayexpress
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