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TranscriptomicsTranscription profiling of rat esophagus treated with N-nitrosomethylbenzylamine to identify the effects of phenylethyl isothiocyanate on N-nitrosomethylbenzylamine-induced cytotoxicity
To date, there is little information on early molecular events in the development of N-nitrosomethylbenzylamine (NMBA) induced esophageal tumorigenesis and of the effects of chemopreventive agents on these events. In this study, we identified genes in rat esophagus that were differentially expressed...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6917 | biostudies-arrayexpress
TranscriptomicsIdentification of GATA1 transcriptional regulation in the megakaryoblastic cell line Meg01
chIP-on-chip analysis of GATA1 in the megakaryoblastic cell line Meg01. The IP was obtained with a GATA1 C-terminus antibody. The control sample was a normal goat IgG pull down done side by side with the GATA1 (C-20) antibody using the same soluble chromatin sample from non-treated Meg-01 cells. A ...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-43018 | biostudies-arrayexpress
GenomicsTranscription factor ChIP-seq in expanded human hematopoietic stem and progenitor cells
While many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models ...
ORGANISM(S): Homo sapiens 
2011-01-26 | E-GEOD-26014 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiles Induced by the Aryl Hydrocarbon Receptor Agonists 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran and 2,3,4,7,8-Pentachlorodibenzofuran in Primary Rat Hepatocytes
Transcriptional profiling of primary rat hepatocytes exposed to high and low doses of three compounds, as well as untreated cells. All samples were co-hybridized with DMSO controls. A direct two-color experiment design, with each treated sample co-hybridized with a DMSO control. Hepatocytes derived...
ORGANISM(S): Rattus norvegicus 
2011-11-01 | E-GEOD-29095 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease
Sex-differences in human liver gene expression were characterized on a genome-wide scale using a large liver sample collection, allowing for detection of small expression differences with high statistical power. 1,249 sex-biased genes were identified, 70% showing higher expression in females. Chromo...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-23766 | biostudies-arrayexpress
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