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TranscriptomicsGene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses
Domoic acid (DA) is a neuroexcitatory amino acid that is naturally produced by some marine diatom species of the genus Pseudo-nitzschia. Ingestion of DA-contaminated seafood by humans results in a severe neurotoxic disease known as amnesic shellfish poisoning (ASP). Clinical signs of ASP include s...
ORGANISM(S): Danio rerio 
2009-07-06 | E-GEOD-12140 | biostudies-arrayexpress
GenomicsSymptomatic Domoic Acid exposure in zebrafish
Symptomatic Domoic Acid exposure in zebrafish
PRJNA640534 | ENA
ProteomicsIdentification of candidate protein biomarkers associated with domoic acid toxicosis in cerebrospinal fluid of California sea lions (Zalophus californianus)
Since 1998, California sea lion stranding events associated with domoic acid toxicosis (DAT) have consistently increased and there are no practical non-lethal clinical tests for the diagnosis of domoic acid toxicosis that can be utilized in a large-scale rehabilitation facility. Proteomic analysis w...
ORGANISM(S): Zalophus californianus (California sealion) 
2023-04-05 | PXD041356 | Pride
Cerebrospinal fluid Lc-msms California sea lion Domoic acid toxicosis 
TranscriptomicsSmall Marine Neurotoxin Elicits Common Antibody Response in Zebrafish and Sea Lions
The neurotoxic amino acid, domoic acid, is naturally produced by marine phytoplankton and presents a significant health threat to marine mammal and human populations. Currently, diagnostic tools to assess exposure are not available, yet concerns regarding health impacts associated with low-level re...
ORGANISM(S): Danio rerio 
2013-01-03 | E-GEOD-34716 | biostudies-arrayexpress
ProteomicsIdentifying candidate markers of domoic acid toxicosis in undepleted plasma from California sea lions (Zalophus californianus)
This data is a re-analysis of samples used in a prior study (doi:10.1371/journal.pone.0123295) evaluating plasma candidate biomarkers of chronic domoic acid toxicosis (DAT) in California sea lions (Zalophus californianus). The previous study used 2D-gel electrophoresis to analyze plasma from a train...
ORGANISM(S): Zalophus californianus (California sealion) 
2020-07-17 | PXD020366 | Pride
Domoic acid Lc-msms California sea lion Plasma 
ProteomicsCalifornia sea lion cerebrospinal fluid LC-MS/MS
We conducted a pilot label-free LC-MS/MS study to profile and compare the cerebral spinal fluid from California sea lions with domoic acid toxicosis and without domoic acid toxicosis. CSF samples from a 8 animals with DAT and 3 controls were run on a nano LC-MS/MS (Triple TOF) and searched against a...
ORGANISM(S): Zalophus californianus (California sealion) 
2015-09-21 | PXD002105 | Pride
Cerebrospinal fluid Domoic acid California sea lion 
Proteomics20240716_DA_standards_dilution_Vivian
raw and mzML files of Domoic acid dilution series for neurotoxin analysis study.
ORGANISM(S): Domoic Acid 
2024-07-16 | MSV000095354 | MassIVE
TranscriptomicsGene expression analysis of late exponential vs. stationary phase cultures using a custom designed Pseudo-nitzschia multiseries (Ps-n) cDNA microarray
Pseudo-nitzschia multiseries (Ps-n) is a toxigenic marine diatom that produces the neurotoxin, domoic acid. We screened for candidate genes that may be involved in domoic acid production by determining changes in transcript profiles in Ps-n cultures that were in late exponential (low-domoic-acid-pro...
ORGANISM(S): Pseudo-nitzschia multiseries 
2013-09-08 | E-GEOD-46845 | biostudies-arrayexpress
GenomicsPseudo-nitzschia multiseries CLN-47
A diatom which produces domoic acid, a neurotoxic amino acid
PRJNA43287 | ENA
GenomicsDomoic acid disruption of neurodevelopment and behavior involves altered myelination in the spinal cord
Domoic acid disruption of neurodevelopment and behavior involves altered myelination in the spinal cord
PRJNA588083 | ENA
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