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GenomicsOSKM factors cooperatively engage chromatin to initiate reprogramming
Reprogramming cells from one fate to another, using transcription factors, generates cells for research and potential therapy, yet little is known about the initial engagement of reprogramming factors with the genome. We mapped the interactions between Oct4, Sox2, Klf4, and c-Myc (OSKM) and the hum...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-36570 | biostudies-arrayexpress
GenomicsMLL1 is essential for the senescence-associated secretory phenotype
This SuperSeries is composed of the SubSeries listed below. Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory respon...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-78142 | biostudies-arrayexpress
GenomicsAcetylation of histone H4 at lysine 44 facilitates meiotic recombination by creating accessible chromatin
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-07 | E-GEOD-59005 | biostudies-arrayexpress
TranscriptomicsExpression data from asynchronous HUH7 cells
During mitosis, RNA polymerase and most transcription factors are excluded from the chromosomes and transcription ceases. The transcriptional re-activation of the genome, following mitosis, requires the re-setting of cell-type specific programs that were initially established during development. H...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-39208 | biostudies-arrayexpress
TranscriptomicsMLL1 is essential for the senescence-associated secretory phenotype [RNA-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78138 | biostudies-arrayexpress
GenomicsAcetylation of histone H4 at lysine 44 facilitates meiotic recombination by creating accessible chromatin [Mnase-seq]
Meiotic recombination hotspots are associated with histone post-translational modifications and open chromatin. However, it remains unclear how histone modifications and chromatin structure directly regulate meiotic recombination. Here, we identify acetylation of histone H4 at Lys44 (H4K44ac) as a n...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-07 | E-GEOD-59004 | biostudies-arrayexpress
TranscriptomicsGene expression changes in the intestinal crypts of mice with loss of imprinting
To identify genes differentially expressed in the intestinal crypts between LOI(+) and LOI(-) mice, we performed microarray experiments using RNA extracted from laser capture microdissection, by microdissecting an average of 8,000 crypts from each of 3 LOI(+) and 3 LOI(-) mice. Keywords: genetic mo...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8583 | biostudies-arrayexpress
GenomicsLarge-scale epigenetic reprogramming is punctuated late during the evolution of pancreatic cancer progression [ChIP-Seq]
During pancreatic cancer progression, heterogeneous subclonal populations evolve in the primary tumor that possess differing capacities to metastasize and cause patient death. However, the genetics of metastasis reflects that of the primary tumor, and PDAC driver mutations arise early. This raises t...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63125 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing analyses of two ants: Camponotus floridanus and Harpegnathos saltator
This SuperSeries is composed of the following subset Series: GSE22678: Transcriptome sequencing and analysis of two ants: Camponotus floridanus and Harpegnathos saltator GSE22679: Small RNA sequencing and analysis of two ants: Camponotus floridanus and Harpegnathos saltator Refer to individual Serie...
ORGANISM(S): Harpegnathos saltator 
2010-08-26 | E-GEOD-22680 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing and analysis of two ants: Camponotus floridanus and Harpegnathos saltator
Deep sequencing of mRNA from two Ants: Camponotus floridanus and Harpegnathos saltator Analysis of poly(A)+ RNA of different specimens: egg,larva,male,minor and major for Camponotus floridanus while egg,larva,male,worker and gammergate for Harpegnathos saltator
ORGANISM(S): Camponotus floridanus 
2010-08-26 | E-GEOD-22678 | biostudies-arrayexpress
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