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TranscriptomicsTranscription profiling of lung tissue from cardiac death and brain death donors, both pre and post transplant
Lung donation after cardiac death (DCD), in contrast to donation after brain death (DBD), is a promising and increasingly common method to help relieve the shortage of donor organs. However, the pathogenetic consequences of retrieved lungs after DCD vs. DBD have not been clarified. We aimed to study...
ORGANISM(S): Homo sapiens 
2009-11-11 | E-GEOD-18995 | biostudies-arrayexpress
ProteomicsBrain death associated activation of Calpain-Talin axis in donor kidneys underlies podocyte matrix degradation and graft dysfunction in kidney transplantation
Deceased kidney donation after brain death (DBD) is the main source of transplants, yet these grafts yield inferior transplant outcomes when compared to living donation. In brain death, cerebral injury contributes to systemic biological dysregulation, causing significant cellular stress in donor kid...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD022074 | Pride
Kidney cytoskeleton Podocytes Donation after brain death (dbd) Protein degradation Allograft dysfunction Kidney transplantation 
UnknownAn international comparison of the effect of policy shifts to organ donation following cardiocirculatory death (DCD) on donation rates after brain death (DBD) and transplantation rates.
Not available
S-EPMC3647074 | biostudies-literature
TranscriptomicsExpression data from donor lungs of cardiac death and brain death donors
Lung donation after cardiac death (DCD), in contrast to donation after brain death (DBD), is a promising and increasingly common method to help relieve the shortage of donor organs. However, the pathogenetic consequences of retrieved lungs after DCD vs. DBD have not been clarified. We aimed to study...
ORGANISM(S): Homo sapiens 
2009-11-12 | GSE18995 | GEO
UnknownA multicenter analysis of lung transplantation outcomes comparing donation after circulatory death and donation after brain death.
Not available
S-EPMC11935477 | biostudies-literature
TranscriptomicsExpression data from donor lungs of cardiac death and brain death donors (re-analysis)
Ischemia reperfusion induced injury contributes to poor lung transplant outcomes.Microarrays were used to study the biological response of human lungs to the ischemia reperfusion process. Samples were collected from lung transplant cases at Toronto General Hospital. Lungs were donation after brain d...
ORGANISM(S): Homo sapiens 
2023-09-18 | GSE127242 | GEO
TranscriptomicsDifferences in gene expression in islets isolated from pancreata donated after Cardiac Death relative to Brain Death
The decreasing numbers of Donation after Brain Death (DBD) donors necessitates the comprehensive evaluation of Donation after Cardiac Death Donors (DCD) as a source of pancreata. The aim of this study was to characterize pancreata and islets from DCD and DBD donors with respect to markers of cellula...
ORGANISM(S): Homo sapiens 
2010-02-09 | GSE14839 | GEO
UnknownHypothermic oxygenated machine perfusion (HOPE) for orthotopic liver transplantation of human liver allografts from extended criteria donors (ECD) in donation after brain death (DBD): a prospective multicentre randomised controlled trial (HOPE ECD-DBD).
Not available
S-EPMC5652559 | biostudies-literature
UnknownKidney Transplant Outcome Following Donation After Euthanasia.
Not available
S-EPMC11425192 | biostudies-literature
UnknownTransplantation of kidneys from DCD and DBD donors who died after ligature asphyxiation: The UK experience.
Not available
S-EPMC6221073 | biostudies-literature
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