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UnknownSevere motor impairment is associated with lower contralesional brain age in chronic stroke.

Background

Stroke leads to complex chronic structural and functional brain changes that specifically affect motor outcomes. The brain-predicted age difference (brain-PAD) has emerged as a sensitive biomarker. Our previous study showed higher global brain-PAD associated with poorer motor func...
S-EPMC11581069 | biostudies-literature
UnknownLongitudinal Weight Loss Patterns and their Behavioral and Demographic Associations.

Background

Identification of weight change patterns may allow tailored interventions to improve long-term weight loss.

Purpose

To identify patterns of weight change over 18 months, and assess participant characteristics and intervention adherence factors associated with weight change ...
S-EPMC4744131 | biostudies-literature
UnknownPLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal.
Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and its long-term integrity. Although regulation of stress responses incurred as a result of HSC activation is recognized as important in maintaining stem cell function, little is understood of the preventive machiner...
S-EPMC9437713 | biostudies-literature
UnknownComparison of different trapping methods to collect malaria vectors indoors and outdoors in western Kenya.

Background

Vector surveillance is among the World Health Organization global vector control response (2017-2030) pillars. Human landing catches are a gold standard but difficult to implement and potentially expose collectors to malaria infection. Other methods like light traps, pyrethrum spr...
S-EPMC10943837 | biostudies-literature
UnknownCancer-specific type-I interferon receptor signaling promotes cancer stemness and effector CD8+ T-cell exhaustion.
Type-I interferon (IFN-I) signaling is critical to maintaining antigen-presenting cell function for anti-tumor immunity. However, recent studies have suggested that IFN-I signaling may also contribute to more aggressive phenotypes, raising the possibility that IFN-I downstream signaling in cancer an...
S-EPMC8632299 | biostudies-literature
UnknownFunctional genomic landscape of cancer-intrinsic evasion of killing by T cells.
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1-3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic T lymphocytes (CTLs), we perfor...
S-EPMC9014559 | biostudies-literature
UnknownLate morning biting behaviour of Anopheles funestus is a risk factor for transmission in schools in Siaya, western Kenya.

Background

Children in Kenya spend a substantial amount of time at school, including at dawn and dusk when mosquitoes are active. With changing vector behaviour towards early morning biting, it is important to determine whether there is an additional risk of transmission in schools. This stu...
S-EPMC10691009 | biostudies-literature
UnknownSingle cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations.
The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RNA sequenci...
S-EPMC6197289 | biostudies-literature
UnknownSphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.
Cellular stress responses serve as crucial decision points balancing persistence or culling of hematopoietic stem cells (HSCs) for lifelong blood production. Although strong stressors cull HSCs, the linkage between stress programs and self-renewal properties that underlie human HSC maintenance remai...
S-EPMC6838675 | biostudies-literature
UnknownSphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.
Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis, driven from leukemia stem cells (LSC) that share some hematopoietic stem cell (HSC) programs including responsiveness to inflammatory signaling. Although inflammation dysregulates mature myeloid cells and influences stemness progr...
S-EPMC7116590 | biostudies-literature
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