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MetabolomicsDonor Gut MicrobialDrives Fecal Microbiota Transplantation Efficacy in ulcerative colitis

Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic strategy for Inflammatory Bowel Disease (UC), though its clinical success appears contingent upon donor microbiota engraftment degree. While microbial colonization dynamics remain poorly understood, our study identifies...

2026-01-11 | MTBLS12531 | MetaboLights
MetabolomicsThe GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis
Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue specific methyltransferases regulates methylation potential. Among them,...
2026-08-18 | MTBLS15161 | MetaboLights
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
MetabolomicsPrimary T Cell Baseline (Donor 5) - II
Not available
ORGANISM(S): Homo sapiens 
ST000144 | MetabolomicsWorkbench
MetabolomicsPrimary T Cell Noxa Knockdown (Donor 8)
Not available
ORGANISM(S): Homo sapiens 
ST000145 | MetabolomicsWorkbench
MetabolomicsPrimary T Cell Noxa Knockdown (Donor 8) III
Not available
ORGANISM(S): Homo sapiens 
ST000370 | MetabolomicsWorkbench
MetabolomicsPrimary T Cell Noxa Knockdown (Donor 8)-II
Not available
ORGANISM(S): Homo sapiens 
ST000153 | MetabolomicsWorkbench
TranscriptomicsGene expression profiling of laparoscopic donor nephrectomy samples compared to healthy control kidneys
We compared gene expression profiles from six donor kidneys prior to surgical manipulation to six kidneys removed after laparoscopic donor nephrectomy (LDN) and several hours of CO2 pneumoperitoneum. Biopsies were obtained from renal cortex and hybridized to Affymetrix HG-U133A GeneChips. For cont...
ORGANISM(S): Homo sapiens 
2005-09-14 | E-GEOD-3297 | biostudies-arrayexpress
MetabolomicsEffects of NO Donor Therapy on the Dystrophic Mouse Quadricep Metabolome (part VIII)
Not available
ORGANISM(S): Mus musculus 
ST000652 | MetabolomicsWorkbench
MetabolomicsEffects of NO Donor Therapy on the Dystrophic Mouse Heart Metabolome (part VII)
Not available
ORGANISM(S): Mus musculus 
ST000651 | MetabolomicsWorkbench
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