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ProteomicsDONSON encodes a novel replication fork protection factor mutated in 2 microcephalic dwarfism.
To ensure efficient genome duplication, cells have evolved a multitude of factors that promote unperturbed DNA replication, and protect, repair and restart damaged forks. Here we identify DONSON as a novel fork protection factor, and report biallelic DONSON mutations in individuals with microcephali...
ORGANISM(S): Homo sapiens (Human) 
2017-02-10 | PXD005690 | Pride
Interaction proteomics 
ProteomicsChromatin proteome of S-phase in IgG- and DONSON-depleted egg extract
The aim of the project was to analyse the role of DONSON during DNA replication reaction in Xenopus laevis egg extract. To test what is the impact of DONSON on replication we decided to remove DONSON from egg extract by immunodepletion and analyse its impact on DNA replication reaction. In the paral...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2023-10-24 | PXD042435 | Pride
Replication initiation Xenopus Donson Chromatin 
GenomicsDONSON encodes a novel replication fork protection factor mutated in microcephalic dwarfism.
To ensure efficient genome duplication, cells have evolved a multitude of factors that promote unperturbed DNA replication, and protect, repair and restart damaged forks. Here we identify DONSON as a novel fork protection factor, and report biallelic DONSON mutations in 29 individuals with microceph...
EGAS00001002224 | EGA
GenomicsDONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain
DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain
PRJNA632751 | ENA
UnknownMutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.
Not available
S-EPMC5450907 | biostudies-literature
UnknownDownstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers.
Not available
S-EPMC7699366 | biostudies-literature
UnknownDONSON is required for CMG helicase assembly in the mammalian cell cycle.
Not available
S-EPMC10626419 | biostudies-literature
UnknownThe structural mechanism of dimeric DONSON in replicative helicase activation.
Not available
S-EPMC7616792 | biostudies-literature
UnknownThe microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons.
Not available
S-EPMC8011756 | biostudies-literature
UnknownNovel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation.
Not available
S-EPMC10476173 | biostudies-literature
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