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ProteomicsThe dopamine transporter antiports potassium to increase the uptake of dopamine
The dopamine transporter facilitates dopamine reuptake from the extracellular space to terminate neurotransmission. The transporter belongs to the neurotransmitter:sodium symporter family, which includes transporters for serotonin, norepinephrine, and GABA that utilize the Na+ gradient to drive the ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-20 | PXD032663 | Pride
Ms  membrane proteins  mass spectroemetry  hydrogen-deuterium exchange  transporter 
ProteomicsSubstrate-induced conformational dynamics of the dopamine transporter
The dopamine transporter is a member of the neurotransmitter:sodium symporters (NSSs), which are responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Experimental evidence elucidating the coordinated conformational rearrangeme...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-11-12 | PXD013841 | Pride
Ms  protein-ligand interactions  membrane proteins  mass spectrometry 
TranscriptomicsMethylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice
Background: Methylphenidate (MPH) a psychostimulant prescribed to manage ADHD symptoms, has been increasingly prescribed to children not meeting the strict criteria for ADHD. It has also been misused as a “cognitive enhancer” and as an alternative to other psychostimulants. Here, we investigate whet...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-33619 | biostudies-arrayexpress
ModelsBest2009 - Homeostatic mechanisms in dopamine synthesis and release
Best2009 - Homeostatic mechanisms in dopamine synthesis and release Encoded non-curated model. Issues: - Initial concentrations for hva, tyrpool, NADPH and NADP are missing - Reaction VMAT requires two substrates to match the formula proposed in the article This model is de...
2015-04-15 | MODEL1502230000 | BioModels
GenomicsCharacterizing the diversity of enteric neurons using Dopamine Transporter (DAT)-Cre reporter mice
Characterizing the diversity of enteric neurons using Dopamine Transporter (DAT)-Cre reporter mice
PRJNA994107 | ENA
ProteomicsDopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
Auxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of-function mutations cause early-onset Parkinson’s disease (PD). Here, we utilized auxilin-knockout (KO) mice to eluci...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-16 | PXD040141 | Pride
Dorsal striatum Substantia nigra Endolysosomal system Dopamine Α-synuclein Clathrin coated vesicles Synaptic autophagy Clathrin mediated endocytosis Axonal deformity Lewy bodies L-dopa 
GenomicsTranscriptional response to amphetamine in Drosophila dopamine transporter (DAT) loss-of-function mutant
Transcriptional response to amphetamine in Drosophila dopamine transporter (DAT) loss-of-function mutant
PRJNA803498 | ENA
TranscriptomicsNorepinephrine transporter-deficient neural crest cells
Background: The goal of this study was to determine the transcriptional consequences of norepinephrine transporter (NET) gene deletion in noradrenergic neuron differentiation. The norepinephrine transporter (NET) is the target of powerful mind-altering substances, such as tricyclic antidepressants a...
ORGANISM(S): Mus musculus 
2008-06-23 | E-GEOD-11788 | biostudies-arrayexpress
UnknownClonorchis sinensis dopamine transporter (CsDAT) facilitates dopamine uptake.
Not available
S-EPMC12400079 | biostudies-literature
UnknownThe dopamine transporter antiports potassium to increase the uptake of dopamine.
Not available
S-EPMC9068915 | biostudies-literature
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