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MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
UnknownInhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease.
Not available
S-EPMC10978283 | biostudies-literature
GenomicsGlobal Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II
We developed a novel approach to isolate and characterize, at nucleotide-level resolution, the RNAs derived from RNA polymerase II (Pol II) in early elongation complexes. We find that high numbers of these short RNAs are not correlated with gene expression but instead are indicative of promoter-prox...
ORGANISM(S): Drosophila melanogaster 
2009-12-11 | E-GEOD-18643 | biostudies-arrayexpress
MetabolomicsInterorganelle lipid flux revealed by enzymatic mass tagging in vivo
The distinct activities of cellular organelles are dependent on the proper function of their membranes. Coordinated membrane biogenesis of the different organelles necessitates interorganelle transport of lipids from their site of synthesis to their destination membranes. Several proteins and traffi...
2022-03-22 | MTBLS3415 | MetaboLights
UnknownRole of miRNAs in Sigmoid Colon Cancer: A Search for Potential Biomarkers.
Not available
S-EPMC7697997 | biostudies-literature
UnknownThe ARIQUELI study: potentiation of quetiapine in bipolar I nonresponders with lithium versus aripiprazole.
Not available
S-EPMC3706295 | biostudies-literature
UnknownEstimate of the incidence of bladder cancer in Africa: A systematic review and Bayesian meta-analysis.
Not available
S-EPMC6409482 | biostudies-literature
UnknownSustained rhoptry docking and discharge requires Toxoplasma gondii intraconoidal microtubule-associated proteins.
Not available
S-EPMC10774369 | biostudies-literature
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
TranscriptomicsThe TCR activation acts as a tumor suppressor mechanism in T-ALL
Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the...
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-65496 | biostudies-arrayexpress
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