Sort   by:  
 Page size 
ProteomicsMechanisms associated with systemic effects of cancer
Cancer is considered as a disease of a specific organ, but its effects are felt throughout the body. The systemic effects of cancer can lead to weakness in muscles and heart, which hastens cancer-associated death. The majority of preclinical studies, including our own, on cancer-induced skeletal mus...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034000 | Pride
Breast cancer Muscle stem cells Skeletal muscle Lc-msms. Mir-486 Cancer cell line Human Biomarker 
ProteomicsTumor tissue collection and processing under physioxia allows highly relevant detection of signaling networks and drug sensitivity of cancer cells
Preclinical studies of primary cancer cells are always done after tumors are removed from patients or animals at ambient atmospheric oxygen (O2, ~21%). However, O2 concentrations in organs are in the ~3-10% range, with most tumors in an hypoxic or 1-2% O2 environment in vivo. Although effects of O2 ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD023133 | Pride
Mouse Tumor Lc-ms/ms 
UnknownBis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.
Not available
S-EPMC11813185 | biostudies-literature
ProteomicsDistinguishing post-translational modifications in dominantly inherited FTD: FTLD-TDP Type A (GRN) versus Type B (C9orf72)
Frontotemporal dementias are neuropathologically characterized by frontotemporal lobar degeneration (FTLD). Intraneuronal inclusions of transactive response DNA-binding protein 43 kDa (TDP-43) are the defining pathologic hallmark of approximately half of the FTLD cases, being referred to as FTLD-TDP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-12 | MSV000089242 | MassIVE
ProteomicsCharacterization of BioID tagging systems in budding yeast and exploring the interactome of the Ccr4-Not complex
The modified E. coli biotin ligase BirA* was the first developed for proximity labeling of proteins (BioID). However, it has low activity at temperatures below 37 C, which reduces its effectiveness in organisms growing at lower temperatures, such as budding yeast. Multiple derivatives of the enzymes...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-05-02 | MSV000094663 | MassIVE
UnknownA multi-omic analysis of the dorsal striatum in an animal model of divergent genetic risk for alcohol use disorder.
Not available
S-EPMC8076345 | biostudies-literature
UnknownA human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle.
Not available
S-EPMC10123345 | biostudies-literature
ProteomicsProteomic Analyses of Plasma from Patients with Fracture Related Infection Reveals Systemic Activation of the Complement and Coagulation Cascades
Patients/Participants: Twenty-seven patients meeting confirmatory FRI criteria were matched to 27 controls based on fracture region, age, and time after surgery Intervention: Tandem Mass Tag (TMT) LC-MS analysis of patient plasma samples Main Outcome Measurements: Abundances for over 1000 proteins w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-15 | MSV000093116 | MassIVE
UnknownIntegrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug.
Not available
S-EPMC12618226 | biostudies-literature
UnknownLoss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism.
Not available
S-EPMC10683835 | biostudies-literature
Sort   by:  
 Page size