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MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
TranscriptomicsExpression data from Down syndrome and non-Down syndrome pediatric acute lymphoblastic leukemia cases
Gene expression profiling (GEP) can reveal characteristic signatures associated with distinct biologic subtypes of acute lymphoblastic leukemia (ALL). We performed GEP on Down syndrome (DS) and comparison non-Down syndrome (NDS) ALL cases to identify biologic differences between these groups. Ficoll...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-20910 | biostudies-arrayexpress
TranscriptomicsIdentification of a DNA methylation signature in blood from subjects affected by Down syndrome
Down syndrome is characterized by a wide spectrum of clinical signs, which include cognitive and endocrine disorders and haematological abnormalities. Although it is well established that the causative defect of Down syndrome is the trisomy of chromosome 21, the molecular bases of Down syndrome phen...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-52588 | biostudies-arrayexpress
TranscriptomicsBiomarkers for Down Syndrome screening in murine fetal liver and placenta
The Ts1Cje mouse strain (Sago, 1998) contains a segmental trisomy of mouse chromosome 16 orthologous to the region of human chromosome 21 commonly associated with Down Syndrome. In this study, fetuses were obtained from wildtype mothers bred with either wildtype or Ts1Cje males. Gene expression prof...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-24272 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects
Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to chara...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-5390 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles of brain samples from Down Syndrome subjects and controls.
Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 486,000 CpGs. Dataset included 71 samples from multiple brain regions (cerebellum, temporal/occipital/frontal cortex). The goal was to evalute the effect of trisomy 21 on DNA methylation levels and e...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-63347 | biostudies-arrayexpress
TranscriptomicsAffymetrix expression arrays from hippocampus of Ms2Yah mouse model of Down syndrome
Affymetrix expression arrays from hippocampus of Ms2Yah mouse model of Down syndrome
ORGANISM(S): Mus musculus 
2012-10-01 | E-MTAB-988 | biostudies-arrayexpress
ProteomicsOlink ExploreHT Plasma Proteomics of Down Syndrome individuals treated with tofacitinib
This dataset contains Olink plasma proteomics of Down Syndrome individuals treated with tofacitinib as part of a clinical trial. These are paired samples before and after treatment.
ORGANISM(S): Homo sapiens (Human) 
2026-09-29 | PAD000062 | Pride
Human Plasma olink explote ht Tofactinib Down syndrome T21 
TranscriptomicsTranscription profiling by array of mouse Ts1Cje (mouse model of Down syndrome) and euploids murine cerebellum during postnatal development
Transcriptome analysis of Ts1Cje (mouse model of Down syndrome) and euploids murine cerebellum during postnatal development Keywords = Down syndrome Keywords = Chromosome 21 Keywords = Transcriptome Keywords = Microarray Keywords = Cerebellum Keywords = Development Keywords: other
ORGANISM(S): Mus musculus 
2004-12-05 | E-GEOD-1611 | biostudies-arrayexpress
TranscriptomicsSNP data from Down syndrome and non-Down syndrome pediatric acute lymphoblastic leukemia cases and controls
SNP profiling can reveal copy number abnormalities and loss of heterozygosity associated with distinct biologic subtypes of acute lymphoblastic leukemia (ALL). We performed SNP profiling of Down syndrome ALL cases and controls to identify unique biologic features of this ALL subgroup. Ficoll-enriche...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-21091 | biostudies-arrayexpress
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