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ProteomicsChIP-MS for GR in liver from wild type and E47 mutant mice
Glucocorticoids (GCs) are widely prescribed effective drugs, but their clinical use is compromised by severe side effects including hyperglycemia, hyperlipidemia and obesity. They bind to the Glucocorticoid Receptor (GR), which acts as a ligand-gated transcription factor. The transcriptional activat...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-22 | PXD010157 | Pride
Coregulator Hormone Steroid receptor Chromatin 
TranscriptomicsTranscription profiling of mouse hearts from mutants lacking estrogen-related receptor alpha (ERRalpha), a nuclear receptor
Total RNA was isolated from 3 WT and 3 ERRalpha null hearts and independent hybridizations were performed using MOE430 2.0 microarrays. Expression profiling was conducted to determine changes in gene expression in hearts lacking ERRa. The expression of genes involved in heart and muscle development,...
ORGANISM(S): Mus musculus 
2007-11-10 | E-GEOD-7196 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fetal heart from wild type and Estrogen-related Receptor gamma (ERRg) knockout strains
3 ventricles from E18.5 male mice were pooled for each array. Three arrays per genotype. Title: ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Post-Natal Heart; Abstract: At birth the heart undergoes a critical metabolic switch to transition from a predominant dependence o...
ORGANISM(S): Mus musculus 
2009-04-30 | E-GEOD-8199 | biostudies-arrayexpress
UnknownG protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.
Not available
S-EPMC9006276 | biostudies-literature
TranscriptomicsTranscription profiling of mouse 3T3-MEFs derived from wild-type and SMRT RID mutants
SMRT (silencing mediator of retinoid and thyroid hormone receptors) is recruited by numerous transcription factors to mediate lineage and signal dependent transcriptional repression. We generated a knock-in mutation in the receptor interaction domain (RID) of SMRT (SMRTmRID) that solely disrupts it...
ORGANISM(S): Mus musculus 
2009-01-18 | E-GEOD-13143 | biostudies-arrayexpress
TranscriptomicsTargeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (strand specific RNA-seq)
Purpose: The purpose of this experiment is to identify expression changes after ASO-dependent depletion of mouse C9orf72 in the spinal cord of wild-type C57Bl/6 female mice. Methods: Strand specific RNA-seq was performed using RNAs extracted from spinal cord of C57Bl/6 mice two weeks after intracere...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-51685 | biostudies-arrayexpress
TranscriptomicsTargeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (Multiplex Analysis of PolyA-linked Sequences)
Purpose: The purpose of this experiment is to identify a C9-ALS/FTD specific genomic profile in fibroblast lines that is distinct from sporadic ALS without C9orf72 expansion and non-neurologic control cells. The study will then evaluate the effect on this identified profile of ASO treatment targetin...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-51684 | biostudies-arrayexpress
GenomicsBP_August_2016_RNA-Seq_hematopoietic_multipotent_progenitor_cell_on_GRCh38 - samples
RNA-Seq data for 3 hematopoietic multipotent progenitor cell sample(s). 9 run(s), 3 experiment(s), 3 analysis(s) on human genome GRCh38. Part of BLUEPRINT release August 2016. Analysis documentation available at http://ftp.ebi.ac.uk/pub/databases/blueprint/releases/20160816/homo_sapiens/README_rnase...
EGAD00001002363 | EGA
GenomicsBP_January_2015_RNA-Seq_CD34-negative,_CD41-positive,_CD42-positive_megakaryocyte_cell - samples
RNA-Seq data for 5 CD34-negative, CD41-positive, CD42-positive megakaryocyte cell sample(s). 23 run(s), 5 experiment(s), 5 alignment(s). Part of BLUEPRINT release January 2015. Analysis documentation available at http://ftp.ebi.ac.uk/pub/databases/blueprint/releases/20140811/homo_sapiens/README_rnas...
EGAD00001001165 | EGA
GenomicsBP_August_2015_RNA-Seq_granulocyte_monocyte_progenitor_cell_on_GRCh38 - samples
RNA-Seq data for 3 granulocyte monocyte progenitor cell sample(s). 3 run(s), 3 experiment(s), 3 alignment(s) on human genome GRCh38. Part of BLUEPRINT release August 2015. Analysis documentation available at http://ftp.ebi.ac.uk/pub/databases/blueprint/releases/20150820/homo_sapiens/README_rnaseq_an...
EGAD00001001501 | EGA
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