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TranscriptomicsResponse of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer.
Objectives ELB-21 is a pyrrolo[2,1-c][1,4]benzodiazepine dimer with potent antistaphylococcal activity; it binds covalently to guanine residues on opposing strands of duplex DNA, interfering with regulatory proteins and transcription elongation in a sequence-selective manner. Transcriptional and pro...
ORGANISM(S): Staphylococcus aureus 
2009-09-18 | E-BUGS-79 | biostudies-arrayexpress
UnknownMolecular comparison of pure ovarian fibroma with serous benign ovarian tumours.
Not available
S-EPMC7376903 | biostudies-literature
UnknownPrevalence of PALB2 mutations in Australian familial breast cancer cases and controls.
Not available
S-EPMC4539664 | biostudies-literature
TranscriptomicsExpression data from Control, AKT and RAS transduced cells
Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes in the same pathway is unclear. Based on a comparative molecular analysis, we show that ac...
ORGANISM(S): Homo sapiens 
2013-03-19 | E-GEOD-45276 | biostudies-arrayexpress
UnknownMicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
Not available
S-EPMC3334977 | biostudies-literature
ProteomicsCDK13 cooperates with CDK12 to control global RNA polymerase II processivity
The RNA polymerase II (POLII) driven transcription cycle is tightly regulated at distinct checkpoints through cyclin dependent kinases (CDKs) and their cognate Cyclins. The molecular events underpinning transcriptional elongation and processivity and CDK-Cyclins involved remain poorly understood. Us...
ORGANISM(S): Homo sapiens (Human) 
2020-04-30 | PXD015453 | Pride
Cdk13 Cdk12 Phosphoproteomics Polymerase 
UnknownA Prospective, Open-Label Pilot Study of Concurrent Male Partner Treatment for Bacterial Vaginosis.
Not available
S-EPMC8524345 | biostudies-literature
UnknownMolecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes.
Not available
S-EPMC4741956 | biostudies-literature
GenomicsThe PUWMa (Pfizer-funded study from the University of California Los Angeles (UCLA), Washington University (WASH-U), and Massachusetts General Hospital (MGH)) GWAS of ADHD

The PUWMa GWAS of ADHD is a multi-site collaboration initiated to conduct a family-based association study from existing research samples. The source sample of ADHD families was ascertained at Massachusetts General Hospital (MGH, N=309 trios), Washington University at St. Louis (WASH-U, N...

phs000358.v1.p1 | EGA
GenomicsInternational Multi-Center ADHD Gene Project (IMAGE) II Case Sample

This sample represents a collection of cases across a range of sites. All of these samples were ascertained for ADHD with most meeting criteria for combined type ADHD. The collection sites span Europe and America. Further details on the source and inclusion and exclusion information can be found ...

phs000407.v1.p1 | EGA
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