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MetabolomicsThe Poly (ADP-Ribose) Polymerase inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells
Breast tumors are characterized into different subtypes based on their surface marker expression, which affects their prognosis and treatment. For example, triple negative breast cancer cells (ER-/PR-/Her2-) show reduced susceptibility towards radiotherapy and chemotherapeutic agents. Poly (ADP-ribo...
2016-11-07 | MTBLS337 | MetaboLights
MetabolomicsMetabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells
Genomic instability is one of the hallmarks of cancer. Several chemotherapeutic drugs and radiotherapy induce DNA damage to prevent cancer cell replication. Cells in turn activate different DNA damage response (DDR) pathways to either repair the damage or induce cell death. These DDR pathways also e...
2015-08-01 | MTBLS177 | MetaboLights
ProteomicsInfluenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
Influenza virus polymerase transcribes or replicates the segmented RNA genome (vRNA) into respectively viral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3' and 5' vRNA ends (the promoter). In recent structures of promoter-bound polymerase, the cap-binding and endo...
ORGANISM(S): Influenza B virus (B/Memphis/13/03) Influenza A virus (A/Vietnam/1203/04(H5N1)) 
2016-01-04 | PXD002234 | Pride
Influenza Xl-ms Polymerase 
ProteomicsDirect Interactions of RNA Polymerase with Ribosomes and Ribosomal Subunits in E. Coli
The interactions between RNA polymerase and ribosomes are critical for the coordination of transcription with translation. We report that RNA polymerase directly binds ribosomes and isolated large and small ribosomal subunits.
ORGANISM(S): Escherichia coli 
2017-08-28 | PXD006717 | Pride
Ribosomes Mass spectrometry E. coli Rna polymerase 
ProteomicsT7 DNA Polymerase with fluorescent unnatural amino acid
A T7 DNA polymerase variant with the fluorescent unnatural amino acid (7-hydroxycoumarin-4-yl) ethylglycine (7-HCou) incorporated at position 514 was expressed in E. coli and purified. The protein was then characterized by mass spec, pre-steady state kinetic experiments, and fluorescence measurement...
ORGANISM(S): Escherichia virus T7 
2020-10-19 | PXD021676 | Pride
T7 Unnatural amino acid Dna polymerase 7-hydroxycoumarin-4-yl ethylglycine 
GenomicsGenomic Study of RNA Polymerase II and III SNAPc-Bound Promoters Reveals a Gene Transcribed by both Enzymes and a Broad Use of Common Activators
SNAPc-dependent promoters are unique among cellular promoters in being very similar to each other, even though some of them recruit RNA polymerase II and other RNA polymerase III. We have examined all SNAPc-bound promoters present in the human genome. We find that there is a surprisingly small numbe...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-38303 | biostudies-arrayexpress
GenomicsDNA polymerase and mismatch repair deficient cancers exert distinct genome-wide microsatellite signatures 2
Whole genome sequencing data for the manuscript: DNA polymerase and mismatch repair deficient cancers exert distinct genome-wide microsatellite signatures
EGAS00001004816 | EGA
TranscriptomicsRNA polymerase II - Mediator interaction
Comparison of genome-wide RNA polymerase II occupancy in wild-type and rpb3-2 yeast strains
ORGANISM(S): Saccharomyces cerevisiae 
2011-10-26 | E-MEXP-3043 | biostudies-arrayexpress
ProteomicsStructure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex, and the Regulation of Transcription
MedPIC: Crosslinking-MS of 54 subunit pre-initiation complex from yeast. MedPolII: Crosslinking-MS of 33 subunit Mediator + polII complex from yeast.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2016-08-02 | MSV000080013 | MassIVE
GenomicsPoised RNA Polymerase II changes over developmental time and prepares genes for future expression (MNase-seq data)
Poised RNA polymerase II is predominantly found at developmental control genes and is thought to allow their rapid and synchronous induction in response to extracellular signals. How the recruitment of poised RNA Pol II is regulated during development is not known. By isolating muscle tissue from Dr...
ORGANISM(S): Drosophila melanogaster 
2012-12-20 | E-GEOD-34283 | biostudies-arrayexpress
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