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TranscriptomicsA comprehensive and universal method for assessing the performance of differential gene expression analyses
The number of methods for pre-processing and analysis of gene expression data continues to increase, often making it difficult to select the most appropriate approach. We present a simple procedure for the comparative estimation of a variety of methods for microarray data pre-processing and analysis...
ORGANISM(S): Homo sapiens 
2010-11-09 | E-GEOD-22630 | biostudies-arrayexpress
TranscriptomicsCLEFMA selectively induces necrotic cell death of H441 lung adenocarcinoma cells via oxidative stress
Despite the growing understanding about the molecular basis of oncogenesis, prevention and cure of cancer remains an unsurpassed challenge. Chemotherapeutic drugs are the mainstay in managing patients diagnosed with any form of cancer. The emergent chemo-resistance, morbid toxicities and overall ine...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-23420 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human alveolar macrophages infected by B. anthracis spores
Bacillus anthracis is a gram-positive, aerobic, spore-forming, rod-shaped bacterium which has recently been used as an agent of bioterrorism. Because there is a significant delay between the initial contact of the spore with the host and clinical evidence of disease, there appears to be temporary co...
ORGANISM(S): Homo sapiens 
2009-10-16 | E-GEOD-14390 | biostudies-arrayexpress
TranscriptomicsGlobal DNA methylation profiling of CD4+ T cells from patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we perfor...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-27895 | biostudies-arrayexpress
UnknownGene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen.
Not available
S-EPMC2752459 | biostudies-literature
ProteomicsTargeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma
Synovial Sarcoma (SS) is driven by the SS18::SSX fusion oncoprotein and is ultimately refractory to therapeutic approaches. SS18::SSX alters ATP-dependent chromatin remodeling BAF (mammalian SWI/SNF) complexes, leading to the degradation of canonical (cBAF) complex and amplified presence of an SS18:...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059936 | Pride
Synovial sarcoma  baf complexes  swi/snf  sumoylation  tak-981  subasumstat  dna damage  targeted therapy 
TranscriptomicsElevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: Implications for prostate cancer progression
Background: Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cance...
ORGANISM(S): Homo sapiens 
2010-08-10 | E-GEOD-20956 | biostudies-arrayexpress
TranscriptomicsSuppression and Activation of the Malignant Phenotype by Extracellular Matrix in Xenograft Models of Bladder Cancer: A Model for Tumor Cell Dormancy
A major problem in cancer research is the lack of a tractable model for delayed metastasis. Herein we show that cancer cells suppressed by SISgel, a gel-forming normal ECM material derived from Small Intestine Submucosa, in flank xenografts show properties of suppression and re-activation that are v...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-35947 | biostudies-arrayexpress
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