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ProteomicsTranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping
Monoamine oxidases MAOA and MAOB catalyze important cellular functions such as the deamination of neurotransmitters. Correspondingly, MAO inhibitors are used for the treatment of severe neuropsychiatric disorders such as depression. A commonly prescribed drug against refractory depression is tranylc...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD018580 | Pride
Human Abpp Lc-ms/ms 
ProteomicsA chemical probe to monitor parkinsonism-associated protein DJ-1 in live cells
Oxidative stress is a contingent trigger of Parkinson`s disease (PD). DJ-1, a protein involved in oxidative stress sensing, gained major attention when mutations in its gene were identified in PD patients. Although the study of the corresponding protein function is still in its infancy, a crucial ox...
ORGANISM(S): Homo sapiens (Human) 
2018-07-17 | PXD009444 | Pride
Human Lc-ms/ms 
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