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GenomicsMolecular mechanism of action of plant DRM de novo DNA methyltransferases
DNA methylation is a conserved epigenetic gene regulation mechanism. DOMAINS REARRANGED METHYLTRANSFERASE (DRM) is a key de novo methyltransferase in plants, but how DRM acts mechanistically is poorly understood. Here, we report the crystal structure of the methyltransferase domain of tobacco DRM (N...
ORGANISM(S): Arabidopsis thaliana 
2014-05-27 | E-GEOD-54944 | biostudies-arrayexpress
TranscriptomicsDRM complex mutant lin-54 vs. H3K36 methyltransferase mutant mes-4 vs. lin-54; mes-4 double mutant vs. wild type C.elegans germline
Here we uncover antagonistic regulation of transcript levels in the germline of Caenorhabditis elegans hermaphrodites. The histone methyltransferase MES-4 marks genes expressed in the germline with methylated Lys36 on histone H3 (H3K36me) and promotes their transcription; MES-4 also represses genes ...
ORGANISM(S): Caenorhabditis elegans 
2013-11-05 | E-GEOD-52064 | biostudies-arrayexpress
TranscriptomicsRNA-seq of a developmentally retarded Chinese cabbage (Brassica campestris ssp. pekinensis) mutant
The leaf of Chinese cabbage is the major place of photosynthesis, the mutation of leaf may directly affect the rate of plant growth and development and the formation of leafy head, and ultimately influence the yield and quality of Chinese cabbage. We identified a developmentally retarded mutant (drm...
ORGANISM(S): Brassica rapa subsp. oleifera 
2016-03-01 | E-GEOD-75464 | biostudies-arrayexpress
GenomicsChromosome-biased binding and gene reguation by the C. elegans DRM complex [ChIP-chip]
DRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we analyze genome-wide binding and function of the C. elegans DRM subunit LIN-54. We demonstrate that LIN-54 DNA-binding activity is required for the...
ORGANISM(S): Caenorhabditis elegans 
2011-04-27 | GSE28852 | GEO
TranscriptomicsGermline and embryo gene expression of wild-type vs. mutants in lin-54, a component of the C. elegans DRM complex
DRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we perform microarray expression profiling analysis of lin-54, a DNA-binding member of the DRM complex. To identify genes regulated by LIN-54 in soma...
ORGANISM(S): Caenorhabditis elegans 
2011-04-09 | E-GEOD-28494 | biostudies-arrayexpress
Methylation profilingMolecular mechanism of action of plant DRM de novo DNA methyltransferases
DNA methylation is a conserved epigenetic gene regulation mechanism. DOMAINS REARRANGED METHYLTRANSFERASE (DRM) is a key de novo methyltransferase in plants, but how DRM acts mechanistically is poorly understood. Here, we report the crystal structure of the methyltransferase domain of tobacco DRM (N...
ORGANISM(S): Arabidopsis thaliana 
2014-05-27 | GSE54944 | GEO
TranscriptomicsGermline and embryo gene expression of wild-type vs. mutants in lin-54, a component of the C. elegans DRM complex
DRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we perform microarray expression profiling analysis of lin-54, a DNA-binding member of the DRM complex. To identify genes regulated by LIN-54 in soma...
ORGANISM(S): Caenorhabditis elegans 
2011-04-09 | GSE28494 | GEO
ProteomicsHuman platelet detergent resistant membranes proteome
Here we characterized the proteins associated with detergent resistant membranes (DRMs) from resting and activated human platelets. We achieved a proteomic profile of 141 DRM proteins involved in many biological pathways including 'PAR-1-mediated thrombin signal events', 'Integrin family cell surfac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080708 | MassIVE
TranscriptomicsChromosome-biased binding and gene reguation by the C. elegans DRM complex [ChIP-chip]
DRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we analyze genome-wide binding and function of the C. elegans DRM subunit LIN-54. We demonstrate that LIN-54 DNA-binding activity is required for th...
ORGANISM(S): Caenorhabditis elegans 
2011-04-27 | E-GEOD-28852 | biostudies-arrayexpress
UnknownChromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex.
Not available
S-EPMC3093354 | biostudies-literature
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