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GenomicsZelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition
The earliest stages of development in most metazoans are driven by maternally deposited proteins and mRNAs, with widespread transcriptional activation of the zygotic genome occurring hours after fertilization, at a period known as the maternal-to-zygotic transition (MZT). In Drosophila, the MZT is p...
ORGANISM(S): Drosophila melanogaster 
2011-07-18 | E-GEOD-30757 | biostudies-arrayexpress
ProteomicsGene expression dynamics before and after zygotic gene activation in Drosophila early embryogenesis
Post-transcriptional gene regulatory mechanisms are fundamental to the determination of gene expression dynamics and especially crucial for the earliest stages of animal development in which transcription is nearly silent. Here we performed high-resolution total RNA-sequencing and quantitative mass ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-09-08 | PXD057383 | Pride
Drosophila mzt development 
TranscriptomicsSMAUG is required for zygotic transcription during the maternal-zygotic transition MZT
Microarray analysis of zygotic gene expression in 2-to-3 hour wild-type (wt) and smg mutant embryos. Expression is relative to mature, stage 14 oocytes, which contain the full maternal pool of mRNA. Strictly maternal genes that are not transcribed at the MZT contribute approximately 80% of transc...
ORGANISM(S): Drosophila melanogaster 
2010-06-19 | E-GEOD-13287 | biostudies-arrayexpress
ProteomicsGENE EXPRESSION DYNAMICS BEFORE AND AFTER ZYGOTIC GENOME ACTIVATION IN DROSOPHILA EARLY EMBRYOGENESIS
Post-transcriptional gene regulatory mechanisms are fundamental for the determination of gene expression dynamics and especially crucial for the earliest stages of animal development in which transcription is nearly silent. Here we performed high-resolution gene expression level change analysis in D...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-09-08 | PXD047784 | Pride
Drosophila Mzt Ubiquitin Rbp 
ProteomicsPrecise temporal regulation of post-transcriptional repressors is required for an orderly Drosophila maternal-to-zygotic transition
In animal embryos the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents over half of the protein coding capacity of the Drosophila melanogaster genome and that 2% of this proteome is rapidly degraded...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-06-05 | PXD016523 | Pride
Development Mzt Ubiquitin Drosophila 
ProteomicsDrosophila mRNA Interactome - Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila
The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the earliest developmental stages, during which maternally deposited mRNAs and other molecules are degraded and replaced by products of the zygotic genome. The zygotic genome is not activated immediately upon fert...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-07-11 | PXD003882 | Pride
Tmt-ms3 Drosophila development Rna-binding proteins 
Proteomics1 Identification of replisome-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry
Replication of the eukaryotic genome requires the assembly of thousands of replisomes that must work in concert to accurately replicate a cell’s genetic and epigenetic information. Defining replisome-associated proteins is a key step in understanding how genomes are replicated and repaired in the co...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-01-27 | PXD031165 | Pride
Dna replication Embryogenesis Drosophila Genome stability Replication fork 
TranscriptomicsmiR-309-dependent unstable maternal mRNAs are stabilized in smaug mutants
The behavior of 410 miR-309-dependent maternal mRNAs (from Bushati et al., 2008) in embryos from wild type and smg-mutant females relative to wild-type stage 14 oocyte reference RNA. All are unstable in wild-type while almost 85% are stabilized in smg mutants mRNA was extracted from staged embryos a...
ORGANISM(S): Drosophila melanogaster 
2010-06-19 | E-GEOD-13288 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila embryos shows the zinc finger protein Zelda plays a key role in the maternal to zygotic transition
In all animals, the initial events of embryogenesis are controlled by maternal gene products that are deposited into the developing oocyte. At some point after fertilization, control of embryogenesis is transferred to the zygotic genome in a process called the maternal to zygotic transition (MZT). D...
ORGANISM(S): Drosophila melanogaster 
2008-11-22 | E-GEOD-11231 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Drosophila melanogaster's primordial germ cells and somatic cells in wild type and smaug mutants
Background: During the maternal-to-zygotic transition (MZT) vast changes in the embryonic transcriptome are produced by a combination of two processes: elimination of maternally provided mRNAs and synthesis of new transcripts from the zygotic genome. Previous genome-wide analyses of the MZT have bee...
ORGANISM(S): Drosophila melanogaster 
2012-02-08 | E-GEOD-34397 | biostudies-arrayexpress
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