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MetabolomicsSearching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug, ...
2021-02-08 | MTBLS873 | MetaboLights
MetabolomicsUntargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ...
2017-06-07 | MTBLS459 | MetaboLights
TranscriptomicsComparative genomic hybridization by array of east haploid and heterozygous essential deletion pools treated with compounds synergistic with fluconazole to identify sensitive and resistant mutants
The haploid and the heterozygous essential S.cerevisiae deletion pools were grown in the presence of compounds that we found to be synergistic with fluconazole. We also treated the deletion pools with combinations of those drugs and fluconazole to interrogate the mechanism of action of the drug inte...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-07 | E-MTAB-394 | biostudies-arrayexpress
GenomicsTranscriptomics analysis of amphotericin B and lactoferrin drug synergy in Cryptococcus neoformans H99
Transcriptomics analysis of amphotericin B and lactoferrin drug synergy in Cryptococcus neoformans H99
PRJNA539938 | ENA
GenomicsDrug synergy slows ageing and improves healthspan through IGF and SREBP lipid signaling
Drug synergy slows ageing and improves healthspan through IGF and SREBP lipid signaling
PRJNA423001 | ENA
TranscriptomicsTranscriptomics analysis of amphotericin B and lactoferrin drug synergy in Cryptococcus neoformans H99
Invasive fungal infections (IFIs) are difficult to treat. Few effective antifungal drugs are available and many have problems with toxicity, efficacy and drug-resistance. To overcome these challenges, existing therapies may be enhanced using more than one agent acting in synergy. Previously, we have...
ORGANISM(S): Cryptococcus neoformans H99 
2019-09-08 | GSE130375 | GEO
TranscriptomicsSynthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma
Recent data demonstrate that extracellular signals are transmitted through a network of proteins rather than hierarchical signaling pathways. This network model suggests why inhibition of a single component of a canonical pathway, even when targeting a mutationally activated driver of cancer, has in...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-39192 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A540 non small cell carcinoma cell lines reveals synergy between PPARgamma ligands and platinum-based drugs in cancer
PPARγ is a member of the nuclear receptor family for which agonist ligands have anti-growth effects. However, clinical studies using PPARγ ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARγ activation with chemotherapeutic agents in current us...
ORGANISM(S): Homo sapiens 
2009-04-30 | E-GEOD-7035 | biostudies-arrayexpress
UnknownSynergyX: a multi-modality mutual attention network for interpretable drug synergy prediction.
Not available
S-EPMC10858681 | biostudies-literature
ProteomicsProteomics analysis of synergistic drug combination of midostaurin and BMS-754807 in Ewing sarcoma ASP14 cell line
We used quantitative mass spectrometry-based proteomics to unravel global changes in the phosphoproteome upon treatment of ASP14 cells (a Ewing Sarcoma cell line) according to the setup below. The combination of drugs were experimentally shown to infer synergy in terms of cell killing. Three experim...
ORGANISM(S): Homo sapiens (Human) 
2017-04-19 | PXD002765 | Pride
Human Lc-msms Drug synergy Ewing sarcoma 
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