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ProteomicsUbiquitin profiling of drug-like small molecule-treated cells
The ubiquitin system regulates eukaryotic physiology by modifying specific substrate proteins. Substrate recognition and the assembly of ubiquitin signals are determined by ubiquitin ligases, some of which also modify non-protein biomolecules. Here we expand this substrate realm, revealing that the ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD067088 | Pride
Drug-like small molecules Digly Ubiquitin Huwe1 
ProteomicsSelective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
The ubiquitin system regulates eukaryotic physiology by modifying specific substrate proteins. Substrate recruitment and the assembly of ubiquitin signals are determined by ubiquitin ligases, some of which also modify non-protein biomolecules. Here we expand this substrate realm, revealing that the ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD066563 | Pride
Small-molecule inhibitor Hect e3 Mass spectrometry Enzymology Click chemistry Non-protein ubiquitination 
ProteomicsIdentification of proteins deregulated by platinum-based chemotherapy as novel biomarkers and therapeutic targets in non-small cell lung cancer
Platinum-based chemotherapy remains the cornerstone of treatment for most people with non-small cell lung cancer (NSCLC), either as adjuvant therapy in combination with a second cytotoxic agent or in combination with immunotherapy. Resistance to therapy, either in the form of primary refractory dise...
ORGANISM(S): Homo Sapiens 
2021-06-15 | PXD024209 | panorama
TranscriptomicsA genome-wide and dose-dependent inhibition map of androgen receptor binding by small molecules reveals its regulatory program upon antagonism
The androgen receptor plays a critical role throughout the progression of prostate cancer and is an important drug target for this disease. While chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-Seq) is becoming an essential tool in studying transcription and chromatin...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-32892 | biostudies-arrayexpress
ProteomicsSelective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
The ubiquitin system regulates myriad pathways in eukaryotic physiology by modifying specific substrate proteins. The recognition of the substrates and the assembly of ubiquitin signals on them – key specificity determinants in ubiquitin signaling - are determined by the diversified class of ubiquit...
ORGANISM(S): Homo sapiens (Human) 
2025-09-03 | PXD063550 | Pride
Small-molecule inhibitor Hect e3 Mass spectrometry Enzymology Click chemistry Non-protein ubiquitination 
UnknownPrinciples for targeting RNA with drug-like small molecules.
Not available
S-EPMC6420209 | biostudies-literature
UnknownDrug-Like Small Molecules That Inhibit Expression of the Oncogenic MicroRNA-21.
Not available
S-EPMC10593481 | biostudies-literature
UnknownQuantum-based machine learning and AI models to generate force field parameters for drug-like small molecules.
Not available
S-EPMC9592901 | biostudies-literature
UnknownSelective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1.
Not available
S-EPMC12405493 | biostudies-literature
UnknownA Versatile Isocyanate-Mediated Strategy for Appending Chemical Tags onto Drug-Like Small Molecules.
Not available
S-EPMC10739574 | biostudies-literature
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