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TranscriptomicsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARFBP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required for growth of colorecta...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-59223 | biostudies-arrayexpress
TranscriptomicsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
HUWE1 was depleted in Ls174T cells with an shRNA and the expression changes relative to a control shRNA were analyzed with microarray. Ls174T cells were treated with two separate HUWE1 inhibitor compounds (BI8622/BI8626) at concentrations of 20 uM and expression profiles relative to DMSO treated con...
ORGANISM(S): Homo_sapiens 
2014-10-22 | E-MTAB-1890 | biostudies-arrayexpress
TranscriptomicsMapping of the HUWE1 duplication at Xp11.22 in eight unrelated XLID patients
In a study to elucidate the genetic defects in patients with X-linked intellectual disability (XLID) we performed X chromosome-specific BAC-array-CGH and identified 0.33 to 1.0 Mb nonrecurrent copy number gains at Xp11.22 in affected males of unrelated XLID families. All aberrations segregate with t...
ORGANISM(S): Homo sapiens 
2012-09-03 | E-GEOD-32945 | biostudies-arrayexpress
ProteomicsQuantitative proteomics to systematically assess protein changes after HUWE1 knockout, in RAW264.7-Dox-Cas9.
Quantitative proteomics to systematically assess protein changes after HUWE1 knockout, in RAW264.7-Dox-Cas9.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-22 | PXD036715 | Pride
Lps Ttp Raw264.7 Psmb7 Macrophages Huwe1 
ProteomicsQuantitative proteomics to systematically assess protein changes after HUWE1 knockout in SW620 and A375 cell line
Quantitative proteomics to systematically assess protein changes after HUWE1 knockout in SW620 and A375 cell line
ORGANISM(S): Homo sapiens (Human) 
2023-03-23 | PXD038892 | Pride
A7375 Sw620 Human Huwe1 
ProteomicsHUWE1 interaction partners in HCT116 cells (TMT)
Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts, TRCs). TRCs can result in DNA damage and underlie genomic instability in tumor cells. Here we provide evidence that elongating RNAPII pro...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD037677 | Pride
Human Wrnip1 Hct116 Huwe1 
ProteomicsHUWE1 interaction partners in HCT116 cells (label free)
Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts, TRCs). TRCs can result in DNA damage and underlie genomic instability in tumor cells. Here we provide evidence that elongating RNAPII pro...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD037812 | Pride
Human Wrnip1 Hct116 Huwe1 
ProteomicsHAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
HUWE1 is a large, enigmatic HECT domain ubiquitin ligase implicated in the degradation of numerous substrates and regulating diverse pathways including DNA repair, apoptosis, and differentiation. However, the mechanism by which HUWE1 acts in a pleiotropic manner to regulate a myriad of substrates is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-14 | PXD041595 | Pride
Ligase Substrates Huwe1 Hapstr1 Ubiquitin 
ProteomicsHAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
HUWE1 is a large, enigmatic HECT domain ubiquitin ligase implicated in the degradation of numerous substrates and regulating diverse pathways including DNA repair, apoptosis, and differentiation. However, the mechanism by which HUWE1 acts in a pleiotropic manner to regulate a myriad of substrates is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-14 | PXD041593 | Pride
Ligase Substrates Huwe1 Hapstr1 Ubiquitin 
ProteomicsHAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
HUWE1 is a large, enigmatic HECT domain ubiquitin ligase implicated in the degradation of numerous substrates and regulating diverse pathways including DNA repair, apoptosis, and differentiation. However, the mechanism by which HUWE1 acts in a pleiotropic manner to regulate a myriad of substrates is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-14 | PXD041590 | Pride
Ligase Substrates Huwe1 Hapstr1 Ubiquitin 
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