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TranscriptomicsTranscription profiling of mouse wild-type and TTP-deficient fibroblast cell lines to identify TTP mRNA targets
Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice, and cells derived from them, showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the rates of mRN...
ORGANISM(S): Mus musculus 
2008-11-22 | E-GEOD-5324 | biostudies-arrayexpress
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [PAR-iCLIP]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-63466 | biostudies-arrayexpress
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [RNA-Seq]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-63467 | biostudies-arrayexpress
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [RNA-Seq_2]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-78209 | biostudies-arrayexpress
TranscriptomicsTristetraprolin (TTP) regulated splenic transcriptome in "Triple KO" mice
Tristetraprolin (TTP) binds to specific AU-rich elements in the 3'UTR of certain transcripts and regulates post-transcriptional gene expression by increasing the rate of mRNA turnover. In this study, we evaluated the effects of TTP deficiency on the overall gene expression of spleen tissue, in ord...
ORGANISM(S): Mus musculus 
2016-03-27 | E-GEOD-60243 | biostudies-arrayexpress
ProteomicsElucidating the Roles of TTP and SMAD2/3 in HEK293T through LC-MS Analysis
To further investigate the mechanism underlying the transcriptional regulation of m6A modification associated genes by TTP. we performed immunoprecipitation using anti-FLAG antibody in HEK293T cells transfected with pHAGE-TTP plasmids (overexpression of TTP) and then used mass spectrometry to identi...
ORGANISM(S): Homo sapiens (Human) 
2026-05-14 | PXD056357 | Pride
Ttp Lc-ms Smad2/3 Hek293t 
TranscriptomicsTristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state [Lymphoma].
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and ...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-37790 | biostudies-arrayexpress
TranscriptomicsTTP-dependent mRNA decay in LPS-stimulated macrophages
Controlled decay of cytokine and chemokine mRNAs restrains the time and amplitude of inflammatory responses. Tristetraprolin (TTP) binds to AU-rich elements in 3´ untranslated regions of mRNA and targets the bound mRNA for degradation. We have addressed here the function of TTP in balancing the macr...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-28880 | biostudies-arrayexpress
ProteomicsPre-mRNA fate decision by TTP safeguards the fidelity of the inflammatory response
Successful immune responses are dependent on a precisely controlled balance between transcription and mRNA degradation. mRNA decay is driven through RNA-binding proteins (RBP), yet it remains unclear, how and when an individual mRNA molecule is selected for degradation. We investigated this fundamen...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-01-27 | PXD046381 | Pride
Mrna decay Pre-mrna binding Resolution of inflammation Inflammation Ttp 
TranscriptomicsGlobal Target mRNA Specification and Regulation by RNA-Binding Protein ZFP36/Tristetraprolin/TTP [PAR-CLIP]
Tristetraprolin/ZFP36/TTP and ELAVL1/HuR are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich sequences but have antagonistic roles. While ELAVL1 binding has been profiled in several studies, the precise in vivo binding specificity of ZFP36 has not been investigated o...
ORGANISM(S): Homo sapiens 
2013-12-24 | E-GEOD-53184 | biostudies-arrayexpress
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