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ProteomicsHAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
HUWE1 is a large, enigmatic HECT domain ubiquitin ligase implicated in the degradation of numerous substrates and regulating diverse pathways including DNA repair, apoptosis, and differentiation. However, the mechanism by which HUWE1 acts in a pleiotropic manner to regulate a myriad of substrates is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-14 | PXD041595 | Pride
Ligase Substrates Huwe1 Hapstr1 Ubiquitin 
ProteomicsHAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
HUWE1 is a large, enigmatic HECT domain ubiquitin ligase implicated in the degradation of numerous substrates and regulating diverse pathways including DNA repair, apoptosis, and differentiation. However, the mechanism by which HUWE1 acts in a pleiotropic manner to regulate a myriad of substrates is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-14 | PXD041593 | Pride
Ligase Substrates Huwe1 Hapstr1 Ubiquitin 
ProteomicsHAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
HUWE1 is a large, enigmatic HECT domain ubiquitin ligase implicated in the degradation of numerous substrates and regulating diverse pathways including DNA repair, apoptosis, and differentiation. However, the mechanism by which HUWE1 acts in a pleiotropic manner to regulate a myriad of substrates is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-14 | PXD041590 | Pride
Ligase Substrates Huwe1 Hapstr1 Ubiquitin 
ProteomicsHAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
HUWE1 is a large, enigmatic HECT domain ubiquitin ligase implicated in the degradation of numerous substrates and regulating diverse pathways including DNA repair, apoptosis, and differentiation. However, the mechanism by which HUWE1 acts in a pleiotropic manner to regulate a myriad of substrates is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-14 | PXD041591 | Pride
Ligase Substrates Huwe1 Hapstr1 Ubiquitin 
ProteomicsChemogenetic Ubiquitin E1 Inhibitor TAK-243 CRISPR Screen Uncovers HAPSTR1/HUWE1 Axis in Chromatin Proteostasis and Cell Cycle Control
We sought to comprehensively map ubiquitin signalling networks at the crossroads of cellular proliferation and proteostasis. Genome-wide CRISPR knock-out screening in the presence of the ubiquitin E1 inhibitor TAK-243 identified 239 genes whose ablation sensitizes cells to ubiquitination blockade. F...
ORGANISM(S): Homo sapiens (Human) 
2026-09-01 | PXD049697 | Pride
Ubiquitin C16orf72 Tak243 Hapstr1 Cell cycle Huwe1 
ProteomicsChemogenetic Ubiquitin E1 Inhibitor TAK-243 CRISPR Screen Uncovers HAPSTR1/HUWE1 Axis in Chromatin Proteostasis and Cell Cycle Control
We sought to comprehensively map ubiquitin signalling networks at the crossroads of cellular proliferation and proteostasis. Genome-wide CRISPR knock-out screening in the presence of the ubiquitin E1 inhibitor TAK-243 identified 239 genes whose ablation sensitizes cells to ubiquitination blockade. F...
ORGANISM(S): Homo sapiens (Human) 
2026-09-01 | PXD074872 | Pride
Cell cycle S phasechromatin proteostasis Hapstr1 Ubiquitin signalling Huwe1 
ProteomicsA Chemogenetic CRISPR Knock-out Screen Uncovers Synergy Between Ubiquitin Signaling and C16orf72/HAPSTR1 for S-phase Entry
Cell cycle progression is orchestrated by complex interplay between post-translational modifications (PTMs) controlling activation (phosphorylation) and degradation (ubiquitination) of key cell cycle regulators. To comprehensively identify ubiquitin signalling components critical for cell proliferat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD050046 | Pride
Dia-ms Ptm Cell cycle Ubiquitination 
UnknownTight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.
Not available
S-EPMC10921065 | biostudies-literature
UnknownAn LRPPRC-HAPSTR1-PSMD14 interaction regulates tumor progression in ovarian cancer.
Not available
S-EPMC11087107 | biostudies-literature
GenomicsC16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways
C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways
PRJNA842777 | ENA
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