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ProteomicsA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1
Telomere erosion contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide screen to identify gene deletions that sensitized p53-positive human cells to loss of telomere integrity, and uncovered a previously unannotated...
ORGANISM(S): Homo sapiens (Human) 
2021-03-04 | PXD022128 | Pride
C16orf72 Crispr-cas9 Genome-wide screen Telomere erosion P53 Telomerase inhibitor 
UnknownC16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption.
Not available
S-EPMC10435583 | biostudies-literature
GenomicsA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [TAPR1_KO]
A genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [TAPR1_KO]
PRJNA674661 | ENA
GenomicsA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [RNA-seq]
A genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [RNA-seq]
PRJNA674657 | ENA
GenomicsA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [BIBR_screen]
A genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [BIBR_screen]
PRJNA674626 | ENA
OtherA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [TAPR1_KO]
Telomere erosion in cells with insufficient levels of the telomerase reverse transcriptase, TERT, contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide screen to identify gene deletions that sensitized p53-positive ...
ORGANISM(S): Homo sapiens 
2021-03-04 | GSE160867 | GEO
OtherA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [BIBR_screen]
Telomere erosion in cells with insufficient levels of the telomerase reverse transcriptase, TERT, contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide screen to identify gene deletions that sensitized p53-positive ...
ORGANISM(S): Homo sapiens 
2021-03-04 | GSE160843 | GEO
UnknownC16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.
Not available
S-EPMC9271168 | biostudies-literature
TranscriptomicsA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1 [RNA-seq]
Telomere erosion in cells with insufficient levels of the telomerase reverse transcriptase, TERT, contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide screen to identify gene deletions that sensitized p53-positive ...
ORGANISM(S): Homo sapiens 
2021-03-04 | GSE160865 | GEO
GenomicsC16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways
C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways
PRJNA842777 | ENA
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