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ProteomicsProteome-based network medicine identifies Gabapentin as a drug to restore viro-induced perturbations of brain circuitryProteome-based network medicine identifies Gabapentin as a drug to restore viro-induced perturbations of brain circuitry
The development of antivirals mostly focuses on viro-centric approaches, but the need for small molecules capable of alleviating the functional perturbations of a tissue induced upon infection is lagging behind. This symptom-oriented complementary strategy used to suffer from the lack of appropriate...
ORGANISM(S): Orthobunyavirus Homo sapiens (Human) 
2026-07-24 | PXD058349 | Pride
Bunyavirus  synapse  antivirals  drug discovery  brain organoids  organotypic culture  neurotropic infection  virus-host interactions. 
ProteomicsHypothesis-generating Proteome Perturbation to Identify Molecular Modes of Drug Action: NEU-4438 and Acoziborole in the African Trypanosome
Aim of the project was to investigate drug induced proteomic changes in T. brucei within 6 h of treatment with NEU-4438 or SCYX-7158
ORGANISM(S): Trypanosoma brucei 
2023-03-11 | PXD036393 | Pride
Trypanosoma brucei Human african trypanosomiasis Drug-perturbome proteomics Silac Neu-4438 Acoziborole Scyx-7158 
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