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ProteomicsHypothesis-generating Proteome Perturbation to Identify Molecular Modes of Drug Action: NEU-4438 and Acoziborole in the African Trypanosome
Aim of the project was to investigate drug induced proteomic changes in T. brucei within 6 h of treatment with NEU-4438 or SCYX-7158
ORGANISM(S): Trypanosoma brucei 
2023-03-11 | PXD036393 | Pride
Trypanosoma brucei Human african trypanosomiasis Drug-perturbome proteomics Silac Neu-4438 Acoziborole Scyx-7158 
ProteomicsGenomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome
SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using a chemo-proteomic approach. SILAC-based proteomic studies using an oxaborole analogue immobilised onto ...
ORGANISM(S): Trypanosoma brucei 
2015-11-25 | PXD002848 | Pride
Trypanosoma brucei 
UnknownHypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome.
Not available
S-EPMC9593816 | biostudies-literature
UnknownOptimal kinetic exposures for classic and candidate antitrypanosomals.
Not available
S-EPMC6640303 | biostudies-literature
UnknownBenzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.
Not available
S-EPMC5976210 | biostudies-literature
UnknownGenomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.
Not available
S-EPMC4689576 | biostudies-literature
UnknownClinical and veterinary trypanocidal benzoxaboroles target CPSF3.
Not available
S-EPMC6156652 | biostudies-literature
GenomicsOxaboroles target trypanosome CPSF3
Oxaboroles target trypanosome CPSF3 - DDD85646 screen
PRJEB25882 | ENA
GenomicsOxaboroles target trypanosome CPSF3 - Acoziborole screen
Oxaboroles target trypanosome CPSF3 - Acoziborole screen
PRJEB25884 | ENA
GenomicsOxaboroles target trypanosome CPSF3
Oxaboroles target trypanosome CPSF3 - SCYX-6759 screen
PRJEB25885 | ENA
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