Druggable targets

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CHEBI ID

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Metabolite Name

Acetyl-CoA_HMDB0001206 (1)
FAD_HMDB0001248 (1)
Coenzyme A_HMDB0001423 (1)
NADP_HMDB0000217 (1)
Stachyose_HMDB0003553 (1)
NADH_HMDB0001487 (1)
NAD_HMDB0000902 (1)
Uridine diphosphate-N-acetylglucosamine_HMDB0000290 (1)
Guanosine diphosphate mannose_HMDB0001163 (1)
Uridine diphosphate glucose_HMDB0000286 (1)
Taurocholic acid_HMDB0000036 (1)
Adenosine triphosphate_HMDB0000538 (1)
Raffinose_HMDB0003213 (1)
Taurodeoxycholic acid_HMDB0000896 (1)
Deoxycholic acid glycine conjugate_HMDB0000631 (1)
Adenosine diphosphate_HMDB0001341 (1)
Sucrose 6-Phosphate_No HMDB data (1)
Cholic acid_HMDB0000619 (1)
3-Oxocholic acid_HMDB0000502 (1)
Uridine 5'-diphosphate_HMDB0000295 (1)
Deoxycholic acid_HMDB0000626 (1)
S-Adenosylhomocysteine_HMDB0000939 (1)
Guanosine monophosphate_HMDB0001397 (1)
Maltitol_HMDB0002928 (1)
Trehalose_HMDB0000975 (1)
Deoxyadenosine monophosphate_HMDB0000905 (1)
Cyclic AMP_HMDB0000058 (1)
Cytidine monophosphate_HMDB0000095 (1)
Nonadecanoic acid_HMDB0000772 (1)
5'-Methylthioadenosine_HMDB0001173 (1)

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Modelling Approach

Constraint-based model (8)
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Lab affiliation

Cancer Research UK Scotland Institute (Formerly the Cancer Research UK Beatson Institute) Garscube Estate Switchback Road Bearsden Glasgow, G61 1BD (2)
Molecular and Cellular Biology, University of Guelph, Canada (2)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA (1)
UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal (1)
Srikant Rangaraju, MD MS Associate Professor Department of Neurology Vascular Neurology Division Emory University (1)
Dana Farber Cancer Institute, Cancer Biology / Harvard Medical School, Biological Chemistry and Molecular Pharmacology (1)
SBBS, Conway Institute, UCD, Belfield, Dublin (1)
Department of Microbiology & Immunology UNC School of Medicine UNC-Chapel Hill (1)
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Proteome Sciences Plc., London (1)
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Molecular proteomics laboratory (MPL), Institut für Molekulare Medizin, Medizinische Fakultät, Heinrich-Heine-Universität, Universitätsstraße 1, D-40225 Düsseldorf (1)
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA (1)
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI), Jena, Germany (1)
Institute for Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Germany (1)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Howard Hughes Medical Institute, Chevy Chase, MD, USA. (1)
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada (1)
European Instutute of Oncology (1)
Dipartimento di medicina Traslazionale, Università del Piemonte Orientale (1)
UK Dementia Research Institute, Department of Clinical Neurosciences, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0AH, UK (1)
Merck Research Laboratories, Boston, MA, USA (1)
Chan Zuckerberg Biohub San Francisco (1)
The Francis Crick Institute, London, NW1 1AT, United Kingdom (1)
Chair of Proteomics and Bioanalytics Technical University of Munich Emil Erlenmeyer Forum 5 85354 Freising Germany (1)
Centre For Targeted Protein Degradation, Unniversity of Dundee, UK (1)
Head of Proteomics and Metabolomics Facility (1)
Centre for targeted protein degradation, University of Dundee (1)
Calico Life Sciences (1)

IsPrivate

False (10)

Submitter Keywords

Not Peer Reviewed (7)
FROG (1)

Classification

viruses (1)

Study type

Transcription profiling by array (19)
RNA-seq of coding RNA (4)
Comparative genomic hybridization by array (2)
Cell line - One-color microarray (1)
ChIP-seq (1)
Methylation profiling by array (1)
RNA-seq of coding RNA from single cells (1)
RNA-seq of total RNA (1)

Release Date

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2017 (91)
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2016 (78)
2015 (56)
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2007 (2)
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Whole genome CRISPRi screening identifies druggable vulnerabilities in drug-resistant Mycobacterium tuberculosis

Tuberculosis (TB) remains a global health threat, aggravated by the emergence of drug-resistant strains. This study aims to identify genes and metabolic pathways with increased vulnerability in drug-resistant Mycobacterium tuberculosis strains compared to their drug-susceptible counterparts. Usin...

2024-10-15 | MTBLS11277 | MetaboLights

Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets

Supporting MS data files for paper (doi:10.3389/fncel.2023.1327361) by Watts M.E. et al., titled "Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets". See attached pdf for index of MS files uploaded.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-10-25 | MSV000093190 | MassIVE

Three-way combinatorial CRISPR screen for analyzing interactions among druggable targets

PRJNA645143 | ENA

Sequence-Derived Markers of Drug Targets and Potentially Druggable Human Proteins.

Not available

S-EPMC6872670 | biostudies-literature

Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study.

Not available

S-EPMC11519603 | biostudies-literature

Evolutionary survey of druggable protein targets with respect to their subcellular localizations.

Not available