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ProteomicsQuantitative characterization of the neuropeptide level changes in dorsal horn and dorsal root ganglia regions of the murine itch models
In this study, we performed a label-free relative quantitation to identify the peptide candidates correlated with itch sensation in murine models. We tested two different itch models-the AEW model (known commonly as the dry skin model) and the MC903 model. Performed peptide extraction from the dorsa...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-23 | PXD015949 | Pride
Lc-ms Extracted ion chromatogram Label-free quantitation 
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
MetabolomicsUntargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Differentiation between IBD and SCL can be diagnostically challenging. We characterized the fecal metabolome of 14 healthy cats and 22 ca...
2021-07-13 | MTBLS440 | MetaboLights
TranscriptomicsTranscription profiling time series of leaves from winter wheat grown under S and N-deficient conditions
Transcripomic analysis of leaf gene expression in S and N-deficient winter wheat during grain development. Tissue was harvested at anthesis and 7, 14 and 21 days post anthesis from experimental field plots.
ORGANISM(S): Triticum aestivum 
2008-09-18 | E-MEXP-1415 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of RET finger protein/ Tripartite protein in human osteosarcoma cell lines and analysis of Retinoblastoma protein dependent transcriptional changes
Analysis of Retinoblastoma protein (Rb) (Hs.408528) dependent transcriptional changes following siRNA mediated ablation of the RET finger protein/ Tripartite protein (RFP/TRIM27) (Hs.440382). Common reference design, two biological replicates with two technical replicates each.
ORGANISM(S): Homo sapiens 
2005-06-02 | E-MEXP-278 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T65H translocation tissues at different developmental stages from mice with or without uniparental duplications of chromosomes 7 and 11 to identify novel imprinted genes
Tissue-specific comparison of gene expression levels in T65H translocation mice, either with or without uniparental duplications of Chrs 7 & 11. Identification of highly differentially expressed transcripts. Experiment Overall Design: Pairwise array comparative analyses were performed using MAS5/GCO...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4870 | biostudies-arrayexpress
MetabolomicsSeasonal and day/night variations of microbial metabolic functioning in simulated cloud water

Microorganisms maintain metabolic activity in clouds, with recognized impacts on chemical reactivity by contributing to the processing of small organic compounds, radicals and their precursors. However, the conditions in clouds can be highly contrasted (temperature, light, etc), and it remains un...

2026-02-12 | MTBLS12281 | MetaboLights
TranscriptomicsCalu6 and LoVo xenograft mRNA expression profiles in response to cediranib treatment
Calu6 and LoVo xenograft mRNA expression profiles in response to cediranib treatment
ORGANISM(S): Homo sapiens 
2013-09-09 | E-MTAB-1627 | biostudies-arrayexpress
ProteomicsProteogenomic Identification and Validation of Key Differentially Expressed Molecular Targets for Keloid Disease
The study incorporated 5 keloid disease (KD) and 5 normal skin (NS) samples, and due to challenges in obtaining primary samples, we had a sample size of 3 biological replicates for FKN, 3 for DFSP made up of 2 primary cells and 1 cell line, and 2 Fibrosarcoma cell lines FS-CL-1 (HT-1080 [HT1080], C...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-29 | MSV000091168 | MassIVE
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-09-23 | MTBLS1474 | MetaboLights
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