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MetabolomicsTear lipidomics profiling reveals inflammatory dry eye disease-associated lipid metabolic remodeling at the ocular surface
This study aimed to investigate whether inflammatory dry eye disease (DED) is accompanied by abnormal lipid metabolic remodeling at the ocular surface. Tear samples were collected from patients with DED and matched healthy controls. Lipidomics profiling was performed using LC–MS/MS with a standardiz...
2026-04-03 | MTBLS14218 | MetaboLights
MetabolomicsTear lipidomics profiling reveals ocular-surface lipid remodeling associated with organelle stress in a mouse model of inflammatory dry eye disease
This study aimed to determine whether dry eye disease (DED) is accompanied by ocular-surface lipid remodeling and whether such changes converge on organelle stress–associated pathways in a mouse model of inflammatory dry eye. Tear samples were collected from mice and analyzed by LC–MS/MS–based non-t...
2026-04-04 | MTBLS14217 | MetaboLights
ProteomicsEffect of acupuncture on tear proteomics in patients with video display terminal-related dry eye
In our study, the tear proteome was compared with identify possible mechanisms and biomarkers for predicting acupuncture effectiveness in VDT-related dry eye. The results showed that the Ocular Surface Disease Index (OSDI) scores were significantly different between the acupuncture group (AC group) ...
ORGANISM(S): Homo Sapiens 
2024-04-24 | PXD051759 |
MetabolomicsAlterations of fecal microbiota and plasma metabolome in patients with Parkinson's disease with rapid eye movement sleep disorder

Objectives: Patients with Parkinson's disease (PD) with probable Rapid eye movement sleep Behavior Disorder (RBD) (PD-RBD), a specific subtype of PD, is characterized by the presence of more severe motor and non-motor symptoms. This study aimed to elucidate the characteristics and interactions of...

2025-05-07 | MTBLS11094 | MetaboLights
MetabolomicsGlobal Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress
“Dry eye” is a multi-factorial inflammatory disease affecting the ocular surface. Tear hyperosmolarity in dry eye contributes to inflammation and cell damage. Recent research efforts on dry eye have been directed towards biomarker discovery for diagnosis, response to treatment and disease mechanisms...
2015-08-31 | MTBLS214 | MetaboLights
ProteomicsHuman Tear using MALDI-TOF-MS for Dry Eye syndrome
Tears are a biological fluid that has diagnostic potential for ocular diseases. Extracellular vesicles (EVs), wildly detected in various biofluids including tears, are nanoparticles released by living cells and considered as promising detection sources for non-invasive liquid biopsy. Understanding t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-20 | PXD020217 | Pride
Human Maldi-tof ms Tear Dry eye syndrome Extracellular vesicles 
ProteomicsAssociation of IL-8 and IL-18 Expression with Histone-Associated NETosis in Aqueous-Deficient and Evaporative Dry Eye Disease
Purpose: Dry eye disease (DED) is a chronic inflammatory disorder of the ocular surface; however, the upstream immune mechanisms contributing to DED are complex and unclear. This study aimed to identify differentially expressed tear fluid proteins in patients with DED and elucidate the underlying di...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075862 | Pride
Tear proteomics Neutrophil degranulation Histones Ocular surface Dry eye And inflammation 
ProteomicsAssociation of IL-8 and IL-18 Expression with Histone-Associated NETosis in Aqueous-Deficient and Evaporative Dry Eye Disease
Purpose: Dry eye disease (DED) is a chronic inflammatory disorder of the ocular surface; however, the upstream immune mechanisms contributing to DED are complex and unclear. This study aimed to identify differentially expressed tear fluid proteins in patients with DED and elucidate the underlying di...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075754 | Pride
Tear proteomics Neutrophil degranulation Histones Ocular surface Dry eye And inflammation 
UnknownLongitudinal Analysis of Tear Cytokine Ratios in Association with Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management (DREAM) Study.
Not available
S-EPMC11774680 | biostudies-literature
ProteomicsIntegrated tear proteome and metabolome reveal panels of inflammatory-related molecules via key regulatory pathways in dry eye syndrome
We applied nanoscale liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (nanoLC/Q-TOF-MS/MS) and ultra-performance LC/Q-TOF-MS/MS technologies on tear samples obtained from 18 dry eye patients and 19 healthy controls for integrated proteomic and metabolomic analyses
ORGANISM(S): Homo Sapiens 
2019-02-28 | PXD012917 |
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