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GenomicsMicrobacterium sp. T-DSG2
Microbacterium sp. T-DSG2 Genome sequencing
PRJNA1446185 | ENA
GenomicsTranscriptomic analysis of DSG2-W2A mouse heart tissue
Transcriptomic analysis of DSG2-W2A mouse heart tissue
PRJNA753782 | ENA
GenomicsRNA-Sequencing of heart tissue obtained from cardiac specific-Dsg2-/- and wild-type (Dsg2+/+) mice at 2-weeks and 10-weeks of age
RNA-Sequencing of heart tissue obtained from cardiac specific-Dsg2-/- and wild-type (Dsg2+/+) mice at 2-weeks and 10-weeks of age
PRJNA641560 | ENA
ProteomicsProximity Labeling and Genetic Screening Reveals the Role of DSG2/Siglec-9 Axis in Suppressing Macrophage Phagocytosis
In current study, we have established a combined strategy using proximity labeling and genetic screening to identify the cellular ligands of Siglec-9. Our use of proximity labeling using APEX2 fusion proteins followed by quantitative proteomics allowed us to efficiently label and enrich cell surface...
ORGANISM(S): Homo sapiens (Human) 
2024-12-23 | PXD051557 | Pride
Siglec-9 Apex2 Dsg2 Proximity label 
TranscriptomicsRNA-Sequencing of heart tissue obtained from cardiac specific-Dsg2-/- and wild-type (Dsg2+/+) mice at 2-weeks and 10-weeks of age
We studied how loss of the desmosome associated protein, desmoglein-2 (Dsg2), in the heart leads to Arrhythmogenic Cardiomyopathy with particular interest in the early stages of disease progression. Mice expressing the cardiac αMHC-Cre promoter were crossed with Dsg2 floxed mice in which exon 4-5 of...
ORGANISM(S): Mus musculus 
2021-07-22 | GSE153124 | GEO
TranscriptomicsTranscriptomic analysis of DSG2-W2A mouse heart tissue
Transcriptomic analysis of DSG2-W2A mouse heart tissue. In DSG2-W2A mice, adhesion of the desmosomal molecule desmoglein-2 (DSG2) is abrogated via mutation of its’ major interaction mechanism (so-called "tryptophan swap" (Harrison, Brasch et al. 2016)). Adult DSG2-W2A mut/mut mice resemble the pheno...
ORGANISM(S): Mus musculus 
2022-12-05 | GSE181868 | GEO
GenomicsThe gene expression effects of DSG2 knockout in A431 epidermoid cell line
The gene expression effects of DSG2 knockout in A431 epidermoid cell line
PRJNA1298353 | ENA
TranscriptomicsAngio-modulation in endothelial cells: an unexpected role of desmoglein-2 in regulating actin dynamics and its relevance to angiogenesis deregulation in systemic sclerosis
Gene expression study of DSG2 silenced human microvascular endothelial cells Affymetrix GeneChip Human Genome U133 Plus 2.0 Array were used to examine differentially expressed genes between normal microvascular endothelial cells and DSG2 silenced microvascular endothelial cells
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-21547 | biostudies-arrayexpress
TranscriptomicsThe gene expression effects of DSG2 knockout in A431 epidermoid cell line
Desmogleins are transmembrane cadherin proteins and obligate members of the desmosome, a cell-cell adhesion complex which connects adjacent cells and provides structural integrity to tissues. While Desmogleins are well-known for their importance in maintenance of cell-cell junctions, several studies...
ORGANISM(S): Homo sapiens 
2025-08-20 | GSE303980 | GEO
UnknownDsg2 Upregulation as a Rescue Mechanism in Pemphigus.
Not available
S-EPMC7655986 | biostudies-literature
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