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ProteomicsProximity Labeling and Genetic Screening Reveals the Role of DSG2/Siglec-9 Axis in Suppressing Macrophage Phagocytosis
In current study, we have established a combined strategy using proximity labeling and genetic screening to identify the cellular ligands of Siglec-9. Our use of proximity labeling using APEX2 fusion proteins followed by quantitative proteomics allowed us to efficiently label and enrich cell surface...
ORGANISM(S): Homo sapiens (Human) 
2024-12-23 | PXD051557 | Pride
Siglec-9 Apex2 Dsg2 Proximity label 
ProteomicsSynthetic Siglec-9 agonists inhibit neutrophil activation associated with COVID-19
Severe cases of coronavirus disease 2019 (COVID-19) are characterized by a hyperinflammatory immune response that leads to numerous complications. Production of proinflammatory neutrophil extracellular traps (NETs) has been suggested to be a key factor in inducing a hyperinflammatory signaling casca...
ORGANISM(S): Homo sapiens (Human) 
2021-07-28 | PXD022990 | Pride
Neutrophil Siglec Netosis Sars-cov-2 Covid-19 
UnknownSiglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties.
Not available
S-EPMC5458540 | biostudies-literature
ProteomicsModulation of immune cell reactivity with cis-binding Siglec-9 agonists
Primary inflammatory pathologies caused by phagocytes lead to numerous debilitating conditions, ranging from chronic pain to permanent blindness. Siglec-9 is an immunoinhibitory receptor expressed on many types of phagocytes and is a promising target for anti-inflammatory therapeutics. We developed ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD018774 | Pride
Phosphoproteomics Tmt Lc-ms/ms 
UnknownDevelopment of Effective Siglec-9 Antibodies Against Cancer.
Not available
S-EPMC9707166 | biostudies-literature
UnknownExpression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells.
Not available
S-EPMC4355580 | biostudies-literature
UnknownSialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9.
Not available
S-EPMC7904912 | biostudies-literature
UnknownSialylated glycoproteins suppress immune cell killing by binding to Siglec-7 and Siglec-9 in prostate cancer.
Not available
S-EPMC11645153 | biostudies-literature
UnknownIncreased expression of Siglec-9 in chronic obstructive pulmonary disease.
Not available
S-EPMC5579055 | biostudies-literature
UnknownSiglec-9 is an inhibitory receptor on human mast cells in vitro.
Not available
S-EPMC10524464 | biostudies-literature
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