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ProteomicsIdentification of Siglec ligands in human B cell
Siglecs are a family of receptor-type glycan recognition proteins (lectins) involved in self - nonself discrimination by the immune system. Identification of Siglec ligand(s) is necessary to understand how Siglec-ligand interaction translates to biological outcomes, but is challenging because the in...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-29 | PXD006359 | Pride
Proteomics Siglec Sialic acid 
TranscriptomicsGene expression profiles of Siglec-14/THP-1 and Siglec-5/THP cell lines, with or without NTHi stimulation
Acquisition of a new strain of non-typeable Haemophilus influenzae (NTHi) is often associated with exacerbation of chronic obstructive pulmonary disease (COPD). We have previously reported that COPD patients who are homozygous null for SIGLEC14 gene is less susceptible to COPD exacerbation than thos...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-47929 | biostudies-arrayexpress
ProteomicsProximity labeling of Siglec-1 counter-receptors on activated regulatory T cells using soluble Siglec-1-HRP multimers
Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. It was shown previously to promote inflammation in autoimmune disease through suppressing the expansion of regulatory T cells (Tregs). We have investigated the molecular basis for Siglec-1 bindin...
ORGANISM(S): Armoracia rusticana Mus musculus (Mouse) Homo sapiens (Human) 
2021-04-28 | PXD021693 | Pride
Proximity labeling Counter-receptor Siglec-1 
ProteomicsProximity labeling of Siglec-1 counter-receptors on activated regulatory T cells using Siglec-1-HRP multimers on nano-beads
Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. It was shown previously to promote inflammation in autoimmune disease through suppressing the expansion of regulatory T cells (Tregs). We have investigated the molecular basis for Siglec-1 bindin...
ORGANISM(S): Armoracia rusticana Mus musculus (Mouse) Homo sapiens (Human) 
2021-04-28 | PXD021691 | Pride
Proximity labeling Counter-receptor Siglec-1 
TranscriptomicsGene expression in liver tissues derived from wild-type and Siglec-E-deficient mice at 55 weeks of age
We show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS m...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-64760 | biostudies-arrayexpress
ProteomicsIdentification of Siglec-7-ligand candidates on JVM-3 human B cell line by proximity labeling
Siglec-7 is a member of Siglec family of glycan recognition proteins involved in the regulation of natural killer (NK) cell activities. We found Siglec-7 ligand is highly expressed on JVM-3, a B cell chronic lymphocytic leukemia (B-CLL) cell line. In this experiment, we attempted at identifying th...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD024690 | Pride
Human Lc-msms Siglec-7 Ligand B cell Sialic acid 
ProteomicsPatient-derived anti-Siglec-6 antibodies engineered into T cell-recruiting bispecific antibody formats for treating leukemia
Despite numerous therapeutic options, safe and curative therapy is out of reach for most chronic lymphocytic leukemia (CLL) patients. We previously reported the identification of a patient-derived CLL-binding antibody, JML-1, and identified Siglec-6 as the target of JML-1. Siglec-6 is an attractive ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-19 | PXD029601 | Pride
Siglec-6 Antibody Hdx-ms 
ProteomicsIdentification of Siglec-E-ligand candidates on BCL-1 mouse B cell line by proximity labeling
Siglec-E is a member of Siglec family of glycan recognition proteins involved in the regulation of myeloid cell activities. Siglec-E preferentially recognizes disialic acid, a glycan epitope consisting of two sialic acids conjugated in alpha2-8 linkage (Zhang JQ et al., Eur J Immunol. 2004, 34:1175...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-25 | PXD013032 | Pride
Lc-msms Siglec-e Mouse Ligand B cell Sialic acid 
TranscriptomicsType-I interferon inducible genes 26 weeks after mCMV infection in Siglec-H wt and Siglec-H ko mice and their non infected controls
Type I interferons are critical anti-viral cytokines during virus infections and have also been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The secretion of type I interferon of pDCs is modulated by Siglec-H, a DAP12 associated receptor on pDCs. We showed that Siglec-H defi...
ORGANISM(S): Mus musculus 
2016-03-16 | E-GEOD-79248 | biostudies-arrayexpress
ProteomicsIdentification of proteins that interact with Siglec-6
Siglec-6 is a glycoprotein overexpressed on chronic lymphocytic leukemia (CLL) cell. We have shown that Siglec-6 promotes migration and adhesion of CLL cells towards CLL bone marrow stromal cells. To elucidate the mechanistic pathway involved in Siglec-6 dependent migration, we performed mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2024-05-08 | PXD039892 | Pride
Human Cell migration Chronic lymphocytic leukemia 
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