Sort   by:  
 Page size 
ProteomicsIdentification of Siglec-E-ligand candidates on BCL-1 mouse B cell line by proximity labeling
Siglec-E is a member of Siglec family of glycan recognition proteins involved in the regulation of myeloid cell activities. Siglec-E preferentially recognizes disialic acid, a glycan epitope consisting of two sialic acids conjugated in alpha2-8 linkage (Zhang JQ et al., Eur J Immunol. 2004, 34:1175...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-25 | PXD013032 | Pride
Lc-msms Siglec-e Mouse Ligand B cell Sialic acid 
TranscriptomicsGene expression in liver tissues derived from wild-type and Siglec-E-deficient mice at 55 weeks of age
We show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS m...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-64760 | biostudies-arrayexpress
ProteomicsExpression of Siglec-E alters the proteome of LPS-activated macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis Expression of Siglec-E alters the proteome of LPS-activated macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis
Siglec-E is a murine CD33-related siglec that functions as an inhibitory receptor and is expressed mainly on neutrophils and macrophage populations. Recent studies have suggested that siglec-E is an important negative regulator of LPS-TLR4 signalling and one report (Wu et al 2016) claimed that sigl...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-09 | PXD008406 | Pride
Mouse bmdm lc-msms 
UnknownSiglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation.
Not available
S-EPMC7784283 | biostudies-literature
UnknownTargeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma.
Not available
S-EPMC11749828 | biostudies-literature
UnknownStudies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.
Not available
S-EPMC5247637 | biostudies-literature
TranscriptomicsGene expression in liver tissues derived from wild-type and Siglec-E-deficient mice at 55 weeks of age
We show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS m...
ORGANISM(S): Mus musculus 
2016-01-15 | GSE64760 | GEO
UnknownSiglec-E deletion alters AT macrophages phenotypes, induces an inflammatory response, and adipogenesis during diet-induced obesity.
Not available
S-EPMC12696692 | biostudies-literature
UnknownSiglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling.
Not available
S-EPMC3596968 | biostudies-literature
GenomicsSingle-cell RNA-seq of 4T1 breast tumors from mice treated with anti-Siglec-E and/or anti-PD-1 antibodies
Single-cell RNA-seq of 4T1 breast tumors from mice treated with anti-Siglec-E and/or anti-PD-1 antibodies
PRJNA1134211 | ENA
Sort   by:  
 Page size