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ProteomicsInvestigating the Cytoprotective Mechanisms of the Tardigrade Damage Suppressor (Dsup) Protein in Human Cells Under Hypoxic Stress
Introduction: Ischemia/reperfusion injury (IRI) is a common damage due to the restoration of blood flow after an ischemic insult. The pathogenesis of IRI is mainly linked to the production of ROS which sustain cell damage and ultimately promote cell death. The tardigrade damage suppressor protein (D...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD067125 | Pride
Ischemia Autophagy Reperfusion Dsup Oxidative stress Proteomic 
TranscriptomicsMultivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage
Tardigrades are remarkable in their ability to survive extreme environments. The damage suppressor (Dsup) protein is thought to contribute to their extreme resistance to reactive oxygen species (ROS) generated by irradiation. Here we show that expression of Ramazzottius varieornatus Dsup in Saccharo...
ORGANISM(S): Saccharomyces cerevisiae 
2025-04-08 | GSE294019 | GEO
OtherMultivalent binding of the tardigrade Dsup protein to heterologous chromatin promotes yeast survival and longevity upon exposure to oxidative damage
Tardigrades are remarkable in their ability to survive extreme environments. The damage suppressor (Dsup) protein is thought responsible for their extreme resistance to reactive oxygen species (ROS) generated by irradiation. Here we show that expression of Ramazzottius varieornatus Dsup in Saccharom...
ORGANISM(S): Saccharomyces cerevisiae 
2024-01-14 | GSE237436 | GEO
UnknownStructural study of the intrinsically disordered tardigrade damage suppressor protein (Dsup) and its complex with DNA.
Not available
S-EPMC11447161 | biostudies-literature
UnknownInvestigating the Cytoprotective Mechanisms of the Tardigrade Damage Suppressor (Dsup) Protein in Human Cells Under Hypoxic Stress.
Not available
S-EPMC12607402 | biostudies-literature
UnknownA computational structural study on the DNA-protecting role of the tardigrade-unique Dsup protein.
Not available
S-EPMC7414916 | biostudies-literature
GenomicsMultivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage
Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage
PRJNA1247871 | ENA
UnknownDSUP modified mesenchymal stem cells exert significant radiation protective effect by enhancing the hematopoietic niche.
Not available
S-EPMC12045013 | biostudies-literature
UnknownThe tardigrade Dsup protein enhances radioresistance in Drosophila melanogaster and acts as an unspecific repressor of transcription.
Not available
S-EPMC10391675 | biostudies-literature
GenomicsMultivalent binding of the tardigrade Dsup protein to heterologous chromatin promotes yeast survival and longevity upon exposure to oxidative damage
Multivalent binding of the tardigrade Dsup protein to heterologous chromatin promotes yeast survival and longevity upon exposure to oxidative damage
PRJNA994949 | ENA
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