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ProteomicsUpregulation of CD73 Confers Acquired Radioresistance and Is Required for Maintaining EMT in the Pancreatic Cancer Cells that Survive Fractionated Irradiation
The molecular mechanisms underlying exceptional radioresistance in pancreatic cancer remain elusive. In the present study, we established a stable radioresistant pancreatic cancer cell line MIA PaCa-2-R by exposing the parental MIA PaCa-2 cells to fractionated ionizing radiation (IR). Systematic pro...
ORGANISM(S): Homo sapiens (Human) 
2019-12-31 | PXD012922 | Pride
Radioresistance Emt Pancreatic cancer Apoptosis Cd73 
ProteomicsEffect of Ipomoeassin F on the Proteome Profile in Triple-Negative Breast Cancer Cells
Ipomoeassin F (Ipom-F) is a natural compound that exhibits a potent cytotoxic effect on triple-negative breast cancer (TNBC) cells. The mechanism underlying this selective potency remains unclear. To elucidate this mechanism, we analyzed the proteome profiles of the TNBC MDA-MB-231 cells after expos...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD060444 | Pride
Breast cancer Human Ipomoeassin f 
ProteomicsProteomic Analysis Reveals the Major Proteins and Pathways that Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells
Despite extensive research, the genes/proteins and biological pathways responsible for the physiological effects of estrogen remain elusive. In this study, we employed a proteomic method to determine the effect of estrogen on global protein expression in breast cancer MCF7 cells. The expression of 7...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049343 | Pride
Estrogen Breast cancer Proteome profiling Quantitative proteomics Cell division Silac Apoptosis. 
ProteomicsSEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization
SEPHS2, a key enzyme in synthesizing selenoproteins, which converts hydrogen selenide into selenophosphate. Here we provide the proteome of SEPHS2 knockout human A375 celllines.
ORGANISM(S): Homo Sapiens 
2026-03-25 | PXD076137 |
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